One-pot synthesis of aromatic homoallylic alcohols from aldehydes and Grignard reagents promoted by Titanium(IV) tetraisopropanolate

被引：2
|
作者：
Song, Xiao-Nan [1 ]
Lu, Lei [1 ]
Hua, Si-Kai [1 ]
Chen, Wei-Dong [1 ]
Ren, Jiangmeng [1 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
来源：
TETRAHEDRON | 2014年 / 70卷 / 43期
基金：
中国国家自然科学基金;
关键词：
Titanium(IV) tetraisopropanolate; Grignard reagents; Homoallylic alcohols; Oxidative arylation; SELECTIVITY ISSUES; COMBINATION; REDUCTION; ALKOXIDES;
D O I：
10.1016/j.tet.2014.08.070
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method of Titanium(IV) mediated one-pot reaction approaching aromatic homoallylic alcohols from aldehydes and dual Grignard reagents was developed with good isolated yields. This method could use aromatic-, heteroaromatic-, or aliphatic-aldehydes as starting materials. However, electronriched benzaldehyde or cinnamaldehyde tended to precede further hydroxyl eliminations to give all conjugated structures as demonstrated. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7881 / 7885
页数：5
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