A 10 ps Time-Resolution CMOS Image Sensor With Two-Tap True-CDS Lock-In Pixels for Fluorescence Lifetime Imaging

被引：44

作者：

Seo, Min-Woong ^{[1
]}

Kagawa, Keiichiro ^{[1
]}

Yasutomi, Keita ^{[1
]}

Kawata, Yoshimasa ^{[1
]}

Teranishi, Nobukazu ^{[1
]}

Li, Zhuo ^{[1
]}

Halin, Izhal Abdul ^{[2
]}

Kawahito, Shoji ^{[1
]}

机构：

[1] Shizuoka Univ, Elect Res Inst, Hamamatsu, Shizuoka 4328011, Japan

[2] Univ Putra Malaysia, Dept Elect & Elect Engn, Upm Serdang 43400, Selanger Darul, Malaysia

来源：

IEEE JOURNAL OF SOLID-STATE CIRCUITS | 2016年 / 51卷 / 01期

关键词：

CMOS image sensor (CIS); fluorescence lifetime imaging microscopy (FLIM); high time resolution; time-resolved imaging; two-tap CMOS lock-in pixel; MODULATION;

D O I：

10.1109/JSSC.2015.2496788

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A CMOS lock-in pixel image sensor with embedded storage diodes and lateral electric field modulation (LEFM) of photo-generated charge is developed for fluorescence lifetime imaging. The time-resolved CMOS image sensor (CIS) with two-tap lock-in pixels achieves a very high time resolution of 10 ps when images are averaged over 30 frames, a very short intrinsic response time of 180 ps at 374 nm, and a low temporal random noise of 1.75e(rms)(-) with true correlated double sampling (CDS) operation. In addition, by using the LEFM and optimized process, a very high extinction ratio of approximately 94% at 472 nm laser diode is achieved. The usefulness of the proposed CIS is demonstrated for fluorescence lifetime imaging with the simulation and measurement results.

引用

页码：141 / 154

页数：14

共 11 条

[1] A 10.8ps-Time-Resolution 256x512 Image Sensor with 2-Tap True-CDS Lock-In Pixels for Fluorescence Lifetime Imaging
Seo, Min-Woong
Kagawa, Keiichiro
Yasutomi, Keita
Takasawa, Taishi
Kawata, Yoshimasa
Teranishi, Nobukazu
Li, Zhuo
Halin, Izhal Abdul
Kawahito, Shoji
2015 IEEE INTERNATIONAL SOLID-STATE CIRCUITS CONFERENCE DIGEST OF TECHNICAL PAPERS (ISSCC), 2015, 58 : 198 - U275
[2] A high time-resolution two-tap CMOS lock-in pixel image sensor for time-resolved measurements and its applications
Seo, Min-Woong
Shirakawa, Yuya
Kagawa, Keiichiro
Yasutomi, Keita
Kawata, Yoshimasa
Teranishi, Nobukazu
Kawahito, Shoji
PROCEEDINGS OF 2016 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS), 2016, : 460 - 463
[3] Time-Resolved Four-Tap Lock-In Pixel CMOS Image Sensor for Real-Time Fluorescence Lifetime Imaging Microscopy
Seo, Min-Woong
Shirakawa, Yuya
Kawata, Yoshimasa
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IEEE JOURNAL OF SOLID-STATE CIRCUITS, 2018, 53 (08) : 2319 - 2330
[4] Development of a two-tap time-resolved CMOS lock-in pixel image sensor with high charge storability and low temporal noise
Seo, Min-Woong
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2017 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS), 2017,
[5] A Programmable Sub-Nanosecond Time-Gated 4-Tap Lock-In Pixel CMOS Image Sensor for Real-Time Fluorescence Lifetime Imaging Microscopy
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[6] A Range Image Sensor Based on 10-μm Lock-In Pixels in 0.18-μm CMOS Imaging Technology
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[7] A Two-Tap NIR Lock-In Pixel CMOS Image Sensor with Background Light Cancelling Capability for Non-Contact Heart Rate Detection
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[8] A Time-Resolved CMOS Image Sensor With Draining-Only Modulation Pixels for Fluorescence Lifetime Imaging
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[9] CMOS image sensor with lateral electric field modulation pixels for fluorescence lifetime imaging with sub-nanosecond time response
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[10] Indirect Time-of-Flight CMOS Image Sensor With On-Chip Background Light Cancelling and Pseudo-Four-Tap/Two-Tap Hybrid Imaging for Motion Artifact Suppression
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