Carcinogenic effect of combined administration of 2,4-diaminoanisole sulfate, 4,4′-thiodianiline and N,N′-diethylthiourea in male Wistar rats

被引：0

作者：

Pomorski, L

Bartos, M ^{[1
]}

Okruszek, A

Matejkowska, M

Tazbir, J

Kuzdak, K

机构：

[1] Med Univ Lodz, Inst Endocrinol, Clin Endocrinol & Gen Surg, PL-93513 Lodz, Poland

[2] Polish Acad Sci, Ctr Mol & Macromol Studies, Lodz, Poland

[3] Copernicus Hosp Lodz, Dept Pathomorphol, Lodz, Poland

[4] Copernicus Hosp Lodz, Dept Gen & Vasc Surg & Emergency Med, Lodz, Poland

来源：

NEOPLASMA | 2002年 / 49卷 / 04期

关键词：

2,4-diaminoanisole sulfate; 4,4 '-thiodianiline; NN '-diethylthiourea; thyroid carcinoma;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Male Wistar rats were divided into two groups. Rats of group 1 were fed basal powdered diet containing 610 ppm 2,4-diaminoanisole sulfate (DAAS), 46 ppm 4,4'-thiodianiline (TDA) and 200 ppm N,N'-diethylthiourea (DETU) for 52 weeks (DTD treatment). Rats of group 2 were maintained on basal diet throughout the experiment as controls. At 52 weeks all surviving rats were sacrificed and subjected to an autopsy. Thyroid, lungs, stomach, liver, spleen, kidneys, testes and all gross lesions suspected of being a tumor were removed. After DTD treatment, the incidence of thyroid hyperplasia and papillary thyroid carcinoma was 59% (10/17) and 65% (11/17), respectively. Hepatocellular adenoma was induced in 2 of 17 rats (12%). Papillary thyroid carcinoma metastasis was found in the lung of 1 rat. No neoplastic tumors were found in kidney, spleen, stomach and testis tissue.

引用

页码：247 / 250

页数：4

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