Recent advancements in oxadiazole-based anticancer agents

被引：22

作者：

Rasool, Irfan ^{[1
]}

Ahmad, Matloob ^{[1
]}

Khan, Zulfiqar Ali ^{[1
]}

Mansha, Asim ^{[1
]}

Maqbool, Tahir ^{[1
]}

Zahoor, Ameer Fawad ^{[1
]}

Aslam, Sana ^{[1
]}

机构：

[1] Govt Coll Univ, Dept Chem, Faisalabad 38000, Pakistan

来源：

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | 2017年 / 16卷 / 03期

关键词：

Oxadiazole ring system; Anticancer activity; Antitumor activity; Cytotoxicity; Apoptosis; BIOLOGICAL EVALUATION; BEARING OXADIAZOLE; DERIVATIVES; ANALOGS; SERIES; 3-ARYL-5-ARYL-1,2,4-OXADIAZOLES; HETEROCYCLES; DISCOVERY; NUCLEUS; DESIGN;

D O I：

10.4314/tjpr.v16i3.30

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxadiazole ring system occupies a significant position among heterocyclic templates for medicinal compounds due to its wide spectrum of biological activities. This article entails an in- depth review of the ability of oxadiazole derivatives to induce apoptosis of cancer cells. FDA has approved a number of drugs for the treatment of different types of cancer. There is, however, a continuing need for the development of new anticancer agents due to increasing cases of drug resistance. Moreover, medicinal chemists are continuously struggling to invent selective cytotoxic agents with minimum side effects. This work reviews the significance of oxadiazole ring system and its potential to act as a template for novel anticancer agents.

引用

页码：723 / 733

页数：11

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