Novel facile synthesis of imidazo[1,2-b]-[1,2,4,5]tetrazines with potential antimicrobial activity

被引：9
|
作者：
Shawali, Ahmad Sami [1 ]
Tawfik, Nagla M. [1 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 07期
关键词：
Hydrazonoyl halides; Nitrilimines; Heterocycles; ONE-POT SYNTHESIS; TAUTOMERIC STRUCTURE; HYDRAZIDOYL HALIDES; HETEROCYCLES; DERIVATIVES;
D O I：
10.1007/s12272-009-1701-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Starting from 1-amino-2-methylthio-4-phenylimidazole 2, a series of the title compounds have been synthesized via its reactions with various hydrazonoyl halides 3. The mechanism of the reactions studied is discussed. The structure of the compounds prepared were elucidated on the basis of their elemental analyses, spectral data and alternate synthesis. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities.
引用
收藏
页码：975 / 982
页数：8
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