Plasma 8-iso-Prostaglandin F2α, a possible prognostic marker in aneurysmal subarachnoid hemorrhage

Background: 8-iso-Prostaglandin F2 alpha (8-iso-PGF2 alpha) is a potential biomarker of oxidative stress. This study clarified whether plasma 8-iso-PGF2 alpha concentrations were affected and its underlying relevance to prognosis in aneurysmal subarachnoid hemorrhage (aSAH). Methods: In this prospective, observational study, a total of 170 controls and 170 aSAH patients were enrolled. Plasma 8-iso-PGF2 alpha concentrations were detected using an ELISA. Severity was assessed by World Federation of Neurological Surgeons (WFNS) scale and modified Fisher grading scale. Clinical outcomes included 6-month mortality and poor outcome referred to as Glasgow outcome scale score of 1-3. Results: As compared to controls, admission plasma 8-iso-PGF2 alpha concentrations were significantly enhanced. Increased concentrations of plasma 8-iso-PGF2 alpha correlated with WFNS scores and modified Fisher scores. 8-isoPGF2 alpha in plasma was an independent predictor for clinical outcomes. Under ROC curve, the predictive values of 8-iso-PGF2 alpha concentrations resembled those of WFNS scores and modified Fisher scores for clinical outcomes. Conclusions: An elevation in plasma 8-iso-PGF2 alpha concentrations is associated with the severity and poor outcome after aSAH, substantializing 8-iso-PGF2 alpha as a potential prognostic biomarker of aSAH.