Synthesis of New Derivatives of 4-(1,4-Benzodioxan-2-yl)thiophene

被引：3
|
作者：
Vardanyan, S. O. [1 ]
Aghekyan, A. A. [1 ]
Avagyan, A. S. [1 ]
Harutyunyan, S. A. [1 ]
Gasparyan, H. V. [1 ]
机构：
[1] Natl Acad Sci Republ Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Ul Azatutyan 26, Yerevan 0014, Armenia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 55卷 / 05期
关键词：
2-acetyl-1; 4-benzodioxane; thiophene; ethyl 2-amino-4-(1; 4-benzodioxan-2-yl)thiophene-3-carboxylate; amido ester; antihypoxic activity;
D O I：
10.1134/S1070428019050038
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
thyl 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate was synthesized by the Gewald reaction of 2-acetyl-1,4-benzodioxane with ethyl 2-cyanoacetate and sulfur in the presence of diethylamine. The product was used to synthesize a series of amido ester derivatives with various pharmacophoric fragments. The antihypoxic properties of the synthesized amido esters were investigated.
引用
收藏
页码：598 / 601
页数：4
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