Amygdala Activation and Emotional Processing in Adolescents at Risk for Substance Use Disorders

被引：5
|
作者：
Lindsay, Dawn L. [1 ]
Pajtek, Stefan [2 ]
Tarter, Ralph E. [2 ]
Long, Elizabeth C. [2 ]
Clark, Duncan B. [2 ]
机构：
[1] Inst Res & Training Addict, Pittsburgh, PA 15219 USA
[2] Univ Pittsburgh, Pittsburgh, PA USA
来源：
JOURNAL OF CHILD & ADOLESCENT SUBSTANCE ABUSE | 2014年 / 23卷 / 03期
关键词：
high risk; functional magnetic resonance imaging (fMRI); adolescents; CHILDHOOD; LIABILITY; FACES; FMRI; MRI;
D O I：
10.1080/1067828X.2014.889515
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Studies are needed that examine neurobiological characteristics in high-risk individuals prior to substance use disorder (SUD) development. In this pilot study, 4 adolescent subjects at high risk for SUD (having at least 1 parent with an SUD) were compared with 4 adolescent reference subjects on a cortico-limbic reactivity paradigm, where they were presented with affect-laden faces or geometric shapes. Functional magnetic resonance imaging was used to measure cortical activation in response to these stimuli. High-risk subjects, compared to low-risk, exhibited greater left amygdala activation (t=2.76, df=6, p=0.03), suggesting they may exhibit hyperresponsivity of the amygdala in response to emotional stimuli.
引用
收藏
页码：200 / 204
页数：5
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