Identifying molecular drivers of gastric cancer through next-generation sequencing

被引：41
|
作者：
Liang, Han [1 ]
Kim, Yon Hui [2 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA
[2] Natl Canc Ctr, New Expt Therapeut Branch, Goyang Si 410769, Gyeonggi Do, South Korea
来源：
CANCER LETTERS | 2013年 / 340卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Somatic mutation; Gastric cancer; Gene fusion; Therapeutic target; Next-generation sequencing; RNA sequencing; SOMATIC MUTATIONS; PHASE-II; CARCINOMA; GENES; CELLS; IDENTIFICATION; EXPRESSION; REVEALS; GENOMES; AGENTS;
D O I：
10.1016/j.canlet.2012.11.029
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastric cancer is the second most common cause of cancer-related death in the world, representing a major global health issue. The high mortality rate is largely due to the lack of effective medical treatment for advanced stages of this disease. Recently next-generation sequencing (NGS) technology has become a revolutionary tool for cancer research, and several NGS studies in gastric cancer have been published. Here we review the insights gained from these studies regarding how use NGS to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets. We also discuss the challenges and future directions of such efforts. Published by Elsevier Ireland Ltd.
引用
收藏
页码：241 / 246
页数：6
相关论文
共 50 条
  • [1] Molecular and pathological analyses of gastric stump cancer by next-generation sequencing and immunohistochemistry
    Masahiro Watanabe
    Takeshi Kuwata
    Ayumi Setsuda
    Masanori Tokunaga
    Akio Kaito
    Shizuki Sugita
    Akiko Tonouchi
    Takahiro Kinoshita
    Masato Nagino
    [J]. Scientific Reports, 11
  • [2] Molecular and pathological analyses of gastric stump cancer by next-generation sequencing and immunohistochemistry
    Watanabe, Masahiro
    Kuwata, Takeshi
    Setsuda, Ayumi
    Tokunaga, Masanori
    Kaito, Akio
    Sugita, Shizuki
    Tonouchi, Akiko
    Kinoshita, Takahiro
    Nagino, Masato
    [J]. SCIENTIFIC REPORTS, 2021, 11 (01)
  • [3] Application of next-generation sequencing in the diagnosis of gastric cancer
    Moradi, Narges
    Moghadam, Solmaz Ohadian
    Heidarzadeh, Siamak
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2022, 57 (07) : 842 - 855
  • [4] Microarray and Next-Generation Sequencing to Analyse Gastric Cancer
    Dang, Yuan
    Wang, Ying-Chao
    Huang, Qiao-Jia
    [J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (19) : 8033 - 8039
  • [5] Next-Generation Sequencing in Cancer
    S. Vinod Nair
    Gigi Madhulaxmi
    Ravindran Thomas
    [J]. Journal of Maxillofacial and Oral Surgery, 2021, 20 : 340 - 344
  • [6] Next-Generation Sequencing in Cancer
    Nair, S. Vinod
    Madhulaxmi
    Thomas, Gigi
    Ankathil, Ravindran
    [J]. JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 2021, 20 (03): : 340 - 344
  • [7] Next-generation sequencing and biomarkers for gastric cancer: what is the future?
    Kawazoe, Akihito
    Shitara, Kohei
    [J]. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2019, 11
  • [8] The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing
    Wyatt, Alexander W.
    Mo, Fan
    Wang, Yuzhuo
    Collins, Colin C.
    [J]. ASIAN JOURNAL OF ANDROLOGY, 2013, 15 (03) : 301 - 308
  • [9] Analyzing Colorectal Cancer at the Molecular Level through Next-generation Sequencing in Erbil City
    Qadir, Vyan A.
    Abdoulrahman, Kamaran K.
    [J]. ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY, 2024, 12 (01):
  • [10] Next-generation sequencing and molecular therapy
    Morton, Cienne
    Sarker, Debashis
    Ross, Paul
    [J]. CLINICAL MEDICINE, 2023, 23 (01): : 65 - 69
12345