Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers

被引:11
|
作者
Kim, Hee-Jin [1 ]
Cho, Sungwoo [1 ]
Oh, Seung Joo [1 ]
Shin, Sung Gyu [1 ]
Ryu, Hee Wook [1 ]
Jeong, Jae Hyun [1 ]
机构
[1] Soongsil Univ, Dept Chem Engn, 369 Sangdo Ro, Seoul 06978, South Korea
来源
MATERIALS | 2019年 / 12卷 / 10期
基金
新加坡国家研究基金会;
关键词
hydrogel; hydrophobicity; self-assembly; degree of swelling; MECHANICAL-PROPERTIES; TISSUE;
D O I
10.3390/ma12101635
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Hydrogels incorporated with hydrophobic motifs have received considerable attention to recapitulate the cellular microenvironments, specifically for the bio-mineralization of a 3D matrix. Introduction of hydrophobic molecules into a hydrogel often results in irregular arrangement of the motifs, and further phase separation of hydrophobic domains, but limited efforts have been made to resolve this challenge in developing the hydrophobically-modified hydrogel. Therefore, this study presents an advanced integrative strategy to incorporate hydrophobic domains regularly in a hydrogel using self-assembled domains formed with polymer cross-linkers, building blocks of a hydrogel. Self-assemblies formed by polymer cross-linkers were examined as micro-domains to incorporate hydrophobic motifs in a hydrogel. The self-assembled structures in a pre-gelled solution were confirmed with the fluorescence analysis and the hydrophobicity of a hydrogel could be tuned by incorporating the hydrophobic chains in a controlled manner. Overall, the results of this study would greatly serve to tuning performance of a wide array of hydrophobically-modified hydrogels in drug delivery, cell therapies and tissue engineering.
引用
收藏
页数:9
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