The innate immune response during urinary tract infection and pyelonephritis

被引：107

作者：

Spencer, John David ^{[1
,2
,3
]}

Schwaderer, Andrew L. ^{[1
,2
,3
]}

Becknell, Brian ^{[1
,2
,3
]}

Watson, Joshua ^{[4
]}

Hains, David S. ^{[1
,2
,3
]}

机构：

[1] Nationwide Childrens Hosp, Dept Pediat, Div Nephrol, Columbus, OH 43205 USA

[2] Nationwide Childrens Hosp, Ctr Clin & Translat Res, Res Inst, Columbus, OH 43205 USA

[3] Nationwide Childrens Hosp, Kidney Innate Immun Res Grp, Res Inst, Columbus, OH 43205 USA

[4] Nationwide Childrens Hosp, Dept Pediat, Div Infect Dis, Columbus, OH 43205 USA

来源：

PEDIATRIC NEPHROLOGY | 2014年 / 29卷 / 07期

关键词：

Urinary tract infection; Pyelonephritis; Innate immunity; Antimicrobial peptides; Toll-like receptors; Chemokines; Cytokines; UROPATHOGENIC ESCHERICHIA-COLI; TOLL-LIKE RECEPTORS; ANTIMICROBIAL PEPTIDE; RIBONUCLEASE; 7; HUMAN BETA-DEFENSIN-1; ALPHA-DEFENSINS; SUSCEPTIBILITY; EXPRESSION; INTERLEUKIN-8; BLADDER;

D O I：

10.1007/s00467-013-2513-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Despite its proximity to the fecal flora, the urinary tract is considered sterile. The precise mechanisms by which the urinary tract maintains sterility are not well understood. Host immune responses are critically important in the antimicrobial defense of the urinary tract. During recent years, considerable advances have been made in our understanding of the mechanisms underlying immune homeostasis of the kidney and urinary tract. Dysfunctions in these immune mechanisms may result in acute disease, tissue destruction and overwhelming infection. The objective of this review is to provide an overview of the innate immune response in the urinary tract in response to microbial assault. In doing so, we focus on the role of antimicrobial peptides-a ubiquitous component of the innate immune response.

引用

页码：1139 / 1149

页数：11

共 50 条

[1] The innate immune response during urinary tract infection and pyelonephritis
John David Spencer
Andrew L. Schwaderer
Brian Becknell
Joshua Watson
David S. Hains
[J]. Pediatric Nephrology, 2014, 29 : 1139 - 1149
[2] A Dynamic Interplay of Innate Immune Responses During Urinary Tract Infection
Naskar, Manisha
Choi, Hae Woong
[J]. IMMUNE NETWORK, 2024, 24 (04)
[3] Urinary tract infection and pyelonephritis
Miller, O
Hemphill, RR
[J]. EMERGENCY MEDICINE CLINICS OF NORTH AMERICA, 2001, 19 (03) : 655 - +
[4] Urinary Tract Infection and Pyelonephritis
Johnson, James R.
[J]. CLINICAL INFECTIOUS DISEASES, 2017, 64 (03) : 390 - 390
[5] Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection
Ulett, Glen C.
Totsika, Makrina
Schaale, Kolja
Carey, Alison J.
Sweet, Matthew J.
Schembri, Mark A.
[J]. CURRENT OPINION IN MICROBIOLOGY, 2013, 16 (01) : 100 - 107
[6] Urinary tract infection in infants: pyelonephritis or not
Halevy, Raphael
Smolkin, Vladislav
Sakran, Waheeb
Haimovitz, Lior
Koren, Ariel
[J]. PEDIATRIC NEPHROLOGY, 2013, 28 (08) : 1383 - 1384
[7] URINARY-TRACT INFECTION AND PYELONEPHRITIS
RITZ, E
TSCHOPE, W
ANDRASSY, K
BOMMER, J
[J]. INNERE MEDIZIN, 1977, 4 (02) : 71 - 75
[8] Urinary Tract Infection and Pyelonephritis Reply
Wagenlehner, Florian M.
Newell, Paul
Yates, Katrina
Gasink, Leanne B.
[J]. CLINICAL INFECTIOUS DISEASES, 2017, 64 (03) : 391 - 391
[9] PYELONEPHRITIS, URINARY-TRACT INFECTION, ANTIBODIES
MOUGENOT, B
LASFARGUES, G
[J]. PEDIATRE, 1976, 12 (55): : 95 - 104
[10] Diagnosis and Management of Urinary Tract Infection and Pyelonephritis
Lane, David R.
Takhar, Sukhjit S.
[J]. EMERGENCY MEDICINE CLINICS OF NORTH AMERICA, 2011, 29 (03) : 539 - +

← 1 2 3 4 5 →