Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger's Disorder

被引：20

作者：

Kleinhans, Natalia M. ^{[1
,3
,4
]}

Richards, Todd ^{[1
,4
]}

Weaver, Kurt E. ^{[1
]}

Liang, Olivia ^{[1
]}

Dawson, Geraldine ^{[2
,3
,4
]}

Aylward, Elizabeth ^{[1
,3
,4
]}

机构：

[1] Univ Washington, Dept Radiol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Psychol, Seattle, WA 98195 USA

[3] Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA

[4] Univ Washington, Autism Ctr, Seattle, WA 98195 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2009年 / 39卷 / 07期

关键词：

Amygdala; Autism; Asperger's disorder; MRS; H-1-MAGNETIC RESONANCE SPECTROSCOPY; PROTON NMR-SPECTRA; IN-VIVO; AMYGDALA THEORY; YOUNG-CHILDREN; HUMAN BRAIN; HIPPOCAMPUS; INTELLIGENCE; ADOLESCENTS; ABILITY;

D O I：

10.1007/s10803-009-0707-6

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger's disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD.

引用

页码：1079 / 1086

页数：8

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