The effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease: A meta-analysis of randomized controlled trials

被引：32
|
作者：
Liu, Yaxin [1 ,2 ,3 ]
Tian, Tao [1 ,2 ,3 ]
Zhang, Huijun [4 ]
Gao, Linggen [5 ]
Zhou, Xianliang [1 ,2 ,3 ]
机构：
[1] Chinese Acad Med Sci, FuWai Hosp, Dept Cardiol, Beijing 100037, Peoples R China
[2] Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China
[3] Peking Union Med Coll, Beijing 100037, Peoples R China
[4] Gen Hosp Beijing Armed Police Corps, Dept Geriatr Cardiol, Beijing 100027, Peoples R China
[5] Gen Hosp Chinese Peoples Liberat Army, Dept Geriatr Cardiol, Beijing 100853, Peoples R China
来源：
ATHEROSCLEROSIS | 2014年 / 235卷 / 01期
基金：
中国博士后科学基金;
关键词：
Homocysteine; Folic acid; Flow-mediated vasodilation; IMPROVES ENDOTHELIAL FUNCTION; ACUTE MYOCARDIAL-INFARCTION; PLACEBO-CONTROLLED TRIAL; FAMILIAL HYPERCHOLESTEROLEMIA; CLINICAL-TRIALS; SUPPLEMENTATION; DYSFUNCTION; HYPERHOMOCYSTEINAEMIA; VITAMINS; HEALTH;
D O I：
10.1016/j.atherosclerosis.2014.03.032
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: High level of homocysteine induces injury of endothelial cells and predicts adverse cardiovascular events. The objective was to assess the effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease. Methods and results: We conducted a meta-analysis of randomized controlled trials identified from PubMed, Embase, the Cochrane Library. Eight studies were included. Homocysteine-lowering therapy with folic acid in patients with coronary artery disease significantly improve FMD as compared with placebo using random-effect model (SMD = 1.65 with 95% CI 1.12-2.17, p < 0.001). Subgroup analysis of subjects revealed that lipid-lowering therapy, study duration, and Delphi criteria had no effects on FMD. Conclusion: Our meta-analysis demonstrated that folic acid supplementation can significantly improve endothelial dysfunction as assessed by FMD in the brachial artery in patients with coronary heart disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：31 / 35
页数：5
相关论文
共 50 条
  • [1] Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: A meta-analysis of randomized controlled trials
    Qin, Xianhui
    Huo, Yong
    Xie, Di
    Hou, Fanfan
    Xu, Xiping
    Wang, Xiaobin
    [J]. CLINICAL NUTRITION, 2013, 32 (05) : 722 - 727
  • [2] The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis
    Potter, Kathleen
    Hankey, Graeme J.
    Green, Daniel J.
    Eikelboom, John
    Jamrozik, Konrad
    Arnolda, Leonard F.
    [J]. BMC CARDIOVASCULAR DISORDERS, 2008, 8 (1)
  • [3] The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis
    Kathleen Potter
    Graeme J Hankey
    Daniel J Green
    John Eikelboom
    Konrad Jamrozik
    Leonard F Arnolda
    [J]. BMC Cardiovascular Disorders, 8
  • [4] A randomised trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease
    Thambyrajah, J
    Landray, MJ
    Wheeler, DC
    Townend, JN
    [J]. CIRCULATION, 2000, 102 (18) : 703 - 703
  • [5] Efficacy of Homocysteine Lowering Therapy With Folic Acid in Stroke Prevention: A Meta-analysis of Randomized Controlled Trials
    Lee, Meng
    Hong, Keun-Sik
    Chang, Shen-Chih
    Saver, Jeffrey L.
    [J]. STROKE, 2010, 41 (04) : E291 - E291
  • [6] Efficacy of Homocysteine-Lowering Therapy With Folic Acid in Stroke Prevention A Meta-Analysis
    Lee, Meng
    Hong, Keun-Sik
    Chang, Shen-Chih
    Saver, Jeffrey L.
    [J]. STROKE, 2010, 41 (06) : 1205 - 1212
  • [7] Effect of Angiotensin Receptor Blockers on Flow-Mediated Vasodilation: A Meta-Analysis of Randomized Controlled Trials
    Chen, Jian-Dong
    Liu, Ming
    Chen, Xiao-hu
    Yang, Zhi-Jian
    [J]. CARDIOLOGY, 2015, 131 (02) : 69 - 79
  • [8] A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease
    Thambyrajah, J
    Landray, MJ
    Jones, HJ
    McGlynn, FJ
    Wheeler, DC
    Townend, JN
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (07) : 1858 - 1863
  • [9] The effect of homocysteine-lowering therapy on endothelium-dependent vasodilation and myocardial ischaemic burden in patients with coronary artery disease
    Aksoy, M
    Gursurer, M
    Akdemir, I
    Emre, A
    Oc, M
    Yazicioglu, V
    Uslu, N
    Ersek, B
    [J]. EUROPEAN HEART JOURNAL, 2000, 21 : 360 - 360
  • [10] Different Doses of Oral Folic Acid for Homocysteine-Lowering Therapy in Patients on Hemodialysis A Randomized Controlled Trial
    Ossareh, Shahrzad
    Shayan-Moghaddam, Hossein
    Salimi, Ashraf
    Asgari, Mojgan
    Farrokhi, Farhat
    [J]. IRANIAN JOURNAL OF KIDNEY DISEASES, 2009, 3 (04) : 227 - 233
12345