Lactonization of C(sp2)H Bonds in Enamides with CO2

被引：42

作者：

Zhang, Zhen ^{[1
,2
]}

Zhu, Chun-Jun ^{[2
]}

Miao, Meng ^{[2
]}

Han, Jie-Lian ^{[2
]}

Ju, Tao ^{[2
]}

Song, Lei ^{[2
]}

Ye, Jian-Heng ^{[2
]}

Li, Jing ^{[2
]}

Yu, Da-Gang ^{[2
,3
]}

机构：

[1] Chengdu Univ, Coll Pharm & Biol Engn, Chengdu 610106, Sichuan, Peoples R China

[2] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan, Peoples R China

[3] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2018年 / 36卷 / 05期

基金：

中国国家自然科学基金;

关键词：

carbon dioxide; transition-metal-free; lactonization; 1,3-oxazin-6-ones; C-H BONDS; TRANSITION-METAL-FREE; CATALYZED OXIDATIVE CARBONYLATION; CARBON-DIOXIDE; PHOTOREDOX CATALYSIS; CARBOXYLIC-ACIDS; RECENT PROGRESS; DERIVATIVES; PALLADIUM; 1,3-OXAZIN-6-ONES;

D O I：

10.1002/cjoc.201700805

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report a novel synthesis of 1,3-oxazin-6-ones from enamides with CO2 through CH carboxylation and one-pot cyclization. This transition-metal-free and redox-neutral process features broad substrate scope, good functional group tolerance and facile product derivatization. The nucleophilic attack to CO2 from the electron-rich alkene is demonstrated for this reaction.

引用

页码：430 / 436

页数：7

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