Secondary Metabolites Produced by Combined Culture of Penicillium crustosum and a Xylaria sp.

被引：53
|
作者：
Yu, Guihong [1 ]
Sun, Zichao [1 ]
Peng, Jixing [3 ]
Zhu, Meilin [1 ]
Che, Qian [1 ]
Zhang, Guojian [1 ,2 ]
Zhu, Tianjiao [1 ,2 ]
Gu, Qjanqun [1 ]
Li, Dehai [1 ,2 ]
机构：
[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Shandong, Peoples R China
[2] Qingdao Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China
[3] Chinese Acad Fishery Sci, Key Lab Testing & Evaluat Aquat Prod Safety & Qua, Minist Agr & Rural Affairs, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 07期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
MARINE-DERIVED FUNGUS; INDUCTION; BIOSYNTHESIS; POLYKETIDES; COCULTURE; ASSAY;
D O I：
10.1021/acs.jnatprod.9b00345
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new alkyl aromatics, penixylarins A-D (1-4), along with the known biogenetically related 1,3-dihydroxy-5-(12-hydroxyheptadecyl)benzene (5) and 1,3dihydroxy-5-(12-sulfoxyheptadecyl)benzene (6), were isolated from a mixed culture of the Antarctic deep-sea-derived fungus Penicillium crustosum PRB-2 and the mangrove-derived fungus Xylaria sp. HDN13-249. UPLC-MS data and an analysis of structural features showed that compounds 1 and 2 were produced by collaboration of the two fungi, while compounds 3-6 could be produced by Xylaria sp. HDN13-249 alone, but in noticeably increased quantities by cocultivation. Compounds 2, 3, 5, and 6 showed antibacterial activity against a panel of strains, and compound 3 possessed potential antituberculosis effects (MIC = 6.25 mu M against Mycobacterium phlei).
引用
收藏
页码：2013 / 2017
页数：5
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