Methyl 2-methoxytetrafluoropropionate as a synthetic equivalent of methyl trifluoropyruvate in the Claisen condensation. The first synthesis of 2-(trifluoroacetyl)chromones and 5-aryl-2-hydroxy-2-(trifluoromethyl)furan-3(2H)-ones

被引：31
|
作者：
Irgashev, Roman A. [1 ]
Sosnovskikh, Vyacheslav Ya [1 ]
Kalinovich, Nataliya [2 ]
Kazakova, Olesya [2 ]
Roeschenthaler, Gerd-Volker [2 ]
机构：
[1] Ural State Univ, Dept Chem, Ekaterinburg 620083, Russia
[2] Univ Bremen, Inst Inorgan & Phys Chem, D-28334 Bremen, Germany
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 34期
关键词：
Methyl; 2-methoxytetrafluoropropionate; Acetophenones; Claisen condensation; Deprotection; Trifluoromethyl 1,2,4-triketones; NICOTINIC-ACID DERIVATIVES; 3,3,3-TRIFLUOROPYRUVATE; 3-(POLYFLUOROACYL)CHROMONES; BENZOPYRONES; TAUTOMERISM; CHEMISTRY; PRODUCTS; ENAMINES;
D O I：
10.1016/j.tetlet.2009.06.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-(Trifluoroacetyl)chromones and 5-aryl-2-liydroxy-2-(trifluoromethyl)furan-3(2H)-ones were obtained in good yields via the Claisen condensation of acetophenones with methyl 2-methoxytetrafluoropropionate, followed by sulfuric acid-mediated deprotection of the reaction products. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4903 / 4905
页数：3
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