Convenient Synthesis of Highly Functionalized α-Cyanothiophene Derivatives via Three-component Reaction

被引：0
|
作者：
Gao Yu-Xiang [1 ,2 ]
Sun Jun
Xu Xian-Xiu [1 ]
Liu Qun [1 ]
机构：
[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China
[2] Tonghua Normal Univ, Dept Chem, Tonghua 134002, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2009年 / 30卷 / 01期
关键词：
Three-component reactions; alpha-Cyanothiophene; 1,3-Dicarbonyl compounds; alpha-Oxo ketene-(S; S)-acetals; BIOLOGICAL EVALUATION; THIOPHENES; DISCOVERY;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A convenient one-pot synthesis of highly functionalized alpha-cyanothiophene derivatives(4) by three-component reactions was developed. In the presence of K2CO3, 1,3-dicarbonyl compounds 1 reacted with CS2 (2) and bromoacetonitrile (3) resulted in the formation of functionalized alpha-cyanothiophenes (4) in high yields. The simplicity of execution, mild conditions, ready availability of substrates and high yields, make this synthetic strategy considerably attractive for academic research and practical applications.
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页码：64 / 67
页数：4
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