The TNF-α-308G/A Polymorphism is Not Associated with Ocular Chlamydia trachomatis Infection in Han Chinese Children

被引：1
|
作者：
Xue, Wenwen [1 ,2 ]
Wang, Qingzhong [3 ]
Li, Zhiqiang [3 ]
Lu, Lina [1 ]
Zhu, Jianfeng [1 ]
He, Xiangui [1 ]
Zhao, Rong [1 ]
Shi, Yongyong [3 ]
Zou, Haidong [1 ,2 ]
机构：
[1] Shanghai Eye Dis Prevent & Treatment Ctr, Dept Preventat Ophthalmol, 380 Kangding Rd, Shanghai 200040, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Ophthalmol, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Minist Educ, BioX Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai 200030, Peoples R China
来源：
OPHTHALMIC GENETICS | 2016年 / 37卷 / 02期
关键词：
Association; chinese population; TNF-alpha-308G/A; trachoma; NECROSIS-FACTOR-ALPHA;
D O I：
10.3109/13816810.2015.1028650
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Objective: To investigate the association between the TNF-alpha-308G/A polymorphism and ocular chlamydia trachomatis (C. Trachomatis) infection among Han Chinese children. Methods: 248 patients and 162 matched healthy controls were recruited. The diagnosis of ocular C. Trachomatis infection was given after clinical observation and latex immunochromatography tests. The TNF-alpha-308G/A polymorphism was genotyped by sequencing. Results: No association was found between the TNF-alpha-308G/A polymorphism and ocular C. Trachomatis infection. Conclusions: The TNF-alpha-308A polymorphism is unlikely to play a major role in the risk for ocular C. Trachomatis in the Chinese population.
引用
收藏
页码：245 / 247
页数：3
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