A practical guide to targeted therapy for bone pain palliation

Targeted radionuclide therapy is an effective and cost efficient treatment for multi-site metastatic bone pain. This paper discusses the physical characteristics of the licensed radiopharmaceuticals Sm-153 ethylenediamine-N,N,N',N'-tetrakis(methylene phosphonic acid) (Sm-153-EDTMP), Re-186 1,1-hydroxyethylidenediphosphonate (Re-186-HEDP) and (SrCl2)-Sr-89 and considers the factors influencing treatment choice in specific clinical settings. The advantages and practical limitations of this approach are discussed, with emphasis on defining criteria for patient selection and response monitoring. Opportunities for future research and development are outlined. ((C) 2002 Lippincott Williams Wilkins).