Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1

被引：14
|
作者：
Zhao, Yawei [1 ]
Yang, Xuehan [1 ]
Zhao, Jingtong [1 ]
Gao, Mohan [1 ]
Zhang, Min [1 ]
Shi, Tongfei [1 ]
Zhang, Fan [1 ]
Zheng, Xiao [1 ]
Pan, Yue [1 ]
Shao, Dan [3 ,4 ]
Li, Jing [1 ]
He, Kan [1 ]
Chen, Li [1 ,2 ]
机构：
[1] Jilin Univ, Dept Pharmacol, Coll Basic Med Sci, Nanomed Engn Lab Jilin Prov, Changchun 130021, Peoples R China
[2] Jilin Univ, Sch Nursing, Changchun 130021, Peoples R China
[3] South China Univ Technol, Inst Life Sci, Sch Biomed Sci & Engn, Guangzhou Int Campus, Guangzhou 510006, Guangdong, Peoples R China
[4] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Sch Biomed Sci & Engn, Guangzhou Int Campus, Guangzhou 510006, Guangdong, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2021年 / 895卷
关键词：
Berberine; Ovarian cancer; Chemotherapy; Migration; Cancer stem cell;
D O I：
10.1016/j.ejphar.2021.173887
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Despite the remarkable clinical response in ovarian cancer therapy, the distinctively high metastasis rate is still a barrier to achieve satisfying prognosis. Our study aimed to decipher the role of berberine in inhibiting chemotherapy-exacerbated ovarian cancer metastasis. We found that chemotherapy exacerbated the migration and cancer stem cell (CSC)-like characteristics through transcriptional factor GLI1, which regulated the pluripotency-associated gene BMI1 and the epithelial-mesenchymal transition (EMT) markers Vimentin and Snail. Berberine could not only down-regulate CSC-like characteristics but also reverse EMT and migration through inhibiting chemotherapy-activated GLI1/BMI1 signaling pathway. Together, our study revealed the pivotal role of berberine in overcoming chemotherapy-exacerbated ovarian cancer metastasis, thereby provided a potential adjuvant therapeutic agent in combination with chemotherapeutics to prevent metastasis during ovarian cancer chemotherapy.
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页数：7
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