The Protective Effect of Radicicol Against Renal Ischemia-Reperfusion Injury in Mice

被引：11

作者：

Sonoda, Hiroko ^{[1
]}

Prachasilchai, Worapat ^{[1
]}

Kondo, Hiroaki ^{[1
]}

Yokota-Ikeda, Naoko ^{[2
]}

Oshikawa, Sayaka ^{[1
]}

Ito, Katsuaki ^{[1
]}

Ikeda, Masahiro ^{[1
]}

机构：

[1] Miyazaki Univ, Fac Agr, Dept Vet Pharmacol, Miyazaki 8892192, Japan

[2] Miyazaki Prefectural Miyazaki Hosp, Dept Internal Med, Miyazaki 8808510, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2010年 / 112卷 / 02期

关键词：

radicicol; renal ischemia-reperfusion injury; heat shock protein 70 kDa (HSP70); UNFOLDED PROTEIN RESPONSE; HEAT-SHOCK PROTEINS; ACUTE KIDNEY INJURY; STRESS; CELLS; INHIBITION; TARGETS; PATHWAY;

D O I：

10.1254/jphs.09259SC

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Overexpression of heat shock protein 70 kDa (HSP70) is known to confer Cellular protection against ischemia-reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we Studied whether radicicol attenuated renal I/R injury in vivo Treatment of mice with radicicol ameliorated renal I/R Injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin.. an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury

引用

页码：242 / 246

页数：5

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