Membrane-protein topology

被引：385
|
作者：
von Heijne, Gunnar [1 ]
机构：
[1] Stockholm Univ, Ctr Biomembrane Res, SE-10691 Stockholm, Sweden
[2] Stockholm Univ, Stockholm Bioinformat Ctr, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 12期
关键词：
D O I：
10.1038/nrm2063
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the world of membrane proteins, topology defines an important halfway house between the amino-acid sequence and the fully folded three-dimensional structure. Although the concept of membrane-protein topology dates back at least 30 years, recent advances in the field of translocon-mediated membrane-protein assembly, proteome-wide studies of membrane-protein topology and an exponentially growing number of high-resolution membrane-protein structures have given us a deeper understanding of how topology is determined and of how it evolves.
引用
收藏
页码：909 / 918
页数：10
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