A facile preparation of pH-temperature dual stimuli-responsive supramolecular hydrogel and its controllable drug release

被引：16
|
作者：
Zhou, Mi [1 ]
Liu, Kaiyue [1 ]
Qian, Xin [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Zhejiang, Peoples R China
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2016年 / 133卷 / 15期
基金：
中国国家自然科学基金;
关键词：
drug delivery systems; gels; self-assembly; stimuli-sensitive polymers; synthesis and processing; POLY(ETHYLENE GLYCOL); BLOCK-COPOLYMER; POLYMERS; PDMAEMA; ENCAPSULATION; GOLD; PEG;
D O I：
10.1002/app.43279
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A series of pH-temperature dual stimuli-responsive random copolymers poly[N,N-dimethylaminoethyl methacrylate-co-poly(poly(ethylene glycol) methyl ether methacrylate][poly(DMAEMA-co-MPEGMA)] were synthesized by free radical polymerization. The supramolecular hydrogel was formed by pseudopolyrotaxane, which was prepared with the host-guest interactions between -cyclodextrin (-CD) and poly(ethylene glycol) (PEG) side chains. Fourier transform infrared (FT-IR), nuclear magnetic resonance (H-1 NMR), and X-ray diffraction (XRD) confirmed the structures of the hydrogels. The pH-temperature dual stimuli responsive properties of the hydrogels were characterized by rheometer. Finally, the controllable drug release behavior of the hydrogel, which was used 5-fluorouracil (5-Fu) as the model drug, was investigated at different temperatures and different pH values. (c) 2015 Wiley Periodicals, Inc.
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页数：7
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