The discovery of new isocyanide-based multi-component reactions

被引：49
|
作者：
Dömling, A [1 ]
机构：
[1] Morphochem AG, D-81379 Munich, Germany
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 03期
关键词：
D O I：
10.1016/s1367-5931(00)00095-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Multi-component reactions are finding increasing use in the discovery process of new drugs and agrochemicals. Some years ago they were considered as highly exotic types of organic reactions. Recently, many groups have realized that the field of multi-component reactions is full of new opportunities. These comprise fast and efficient production of small-molecular-weight compound libraries, highly atom-economic chemistry, very large chemical libraries, improvements in total synthesis, and applications in bioconjugate chemistry, as well as in related fields (e.g. chemical biology).
引用
收藏
页码：318 / 323
页数：6
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