Cigarette Smoking and Cutaneous Damage in Systemic Lupus Erythematosus

被引:36
|
作者
Turchin, Irina [3 ]
Bernatsky, Sasha [1 ,2 ]
Clarke, Ann E. [1 ,4 ]
St-Pierre, Yvan [1 ,4 ]
Pineau, Christian A. [2 ]
机构
[1] McGill Univ, Res Inst, Ctr Hlth, Div Clin Epidemiol,Dept Med, Montreal, PQ H3A 1A1, Canada
[2] McGill Univ, Dept Med, Ctr Hlth, Div Rheumatol, Montreal, PQ H3A 1A1, Canada
[3] McGill Univ, Ctr Hlth, Div Gen Internal Med, Dept Med, Montreal, PQ H3A 1A1, Canada
[4] McGill Univ, Ctr Hlth, Div Allergy & Clin Immunol, Dept Med, Montreal, PQ H3A 1A1, Canada
关键词
SYSTEMIC LUPUS ERYTHEMATOSUS; DISEASE ACTIVITY; SMOKING; SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX; SKIN;
D O I
10.3899/jrheum.090403
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To evaluate the association between cigarette smoking and cutaneous damage in systemic lupus erythematosus (SLE). Methods. Our study was performed in SLE clinic registry cohort patients, all of whom fulfilled revised American College of Rheumatology criteria for SLE; patients are followed prospectively with annual assessments that include collection of demographic variables, smoking history, disease activity (SLE Disease Activity Index version 2000, SLEDAI-2K), medications, and damage scores (Systemic Lupus International Collaborating Clinics/ACR Damage Index). Cumulative cutaneous damage scores were used for the primary analyses. Logistic and logit regression models were performed to examine potential associations between current smoking and cutaneous damage, controlling for age, sex, race, lupus disease duration, antimalarial or immunosuppressant use, and anti-DNA and anti-SSA antibody status. Results. Of our sample (N = 276), 92% were women and 73.7% were Caucasian: the mean age was 45.1 years. mean disease duration 13.5 years, and 17.5% were current smokers. In the regression analyses, current cigarette smoking was associated with total cutaneous damage (OR 2.73, 95% CI 1.10, 6.81) and with scarring (OR 4.70, 95 CI 1.04, 21.2). In additional analyses, current smoking was also associated with active lupus rash (OR 6.18 95% CI 1.63, 23.3). Conclusions. Current cigarette smoking may be associated with cutaneous damage and active lupus rash in SLE, suggesting another reason to emphasize smoking cessation in patients with SLE. (First Release Nov 1 2009; J Rheumatol 2009; 36:2691-3; doi:10.3899/jrheum.090403)
引用
收藏
页码:2691 / 2693
页数:3
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