Epigenetic modulation of SSTR2 expression provides the potential to broaden PEN-221 treatment population

被引:1
|
作者
Perino, Samantha [1 ]
Quinn, James [1 ]
Freda, Jessica [1 ]
White, Brian [1 ]
Bailey, Scott [1 ]
Bhatia, Viren [1 ]
Sweryda-Krawiec, Beata [1 ]
Bilodeau, Mark [1 ]
Bloss, Jeffrey D. [1 ]
Whalen, Kerry [1 ]
Wooster, Richard [1 ]
机构
[1] Tarveda Therapeut, Watertown, MA USA
关键词
D O I
10.1158/1538-7445.SABCS18-4328
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4328
引用
收藏
页数:2
相关论文
共 16 条
  • [1] Discovery of PEN-221, an SSTR2-targeting maytansinoid conjugate with potent activity in vitro and in vivo
    White, Brian H.
    Bazinet, Patrick
    Whalen, Kerry
    DuPont, Michelle
    Quinn, James M.
    Alargova, Rossitza
    Yeung, Tsun Au
    Brockman, Adam
    Gifford, James
    Oller, Haley
    Kriksciukaite, Kristina
    Lemelin, Charles-Andre
    Soo, Patrick Lim
    Moreau, Benoit
    Perino, Samantha
    Sharma, Gitanjali
    Shinde, Rajesh
    Sweryda-Krawiec, Beata
    Simcox, Mary
    Wooster, Richard
    Bilodeau, Mark T.
    CANCER RESEARCH, 2017, 77
  • [2] Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo
    White, Brian H.
    Whalen, Kerry
    Kriksciukaite, Kristina
    Alargova, Rossitza
    Yeung, Tsun Au
    Bazinet, Patrick
    Brockman, Adam
    DuPont, Michelle
    Oller, Haley
    Lemelin, Charles-Andre
    Soo, Patrick Lim
    Moreau, Benoit
    Perino, Samantha
    Quinn, James M.
    Sharma, Gitanjali
    Shinde, Rajesh
    Sweryda-Krawiec, Beata
    Wooster, Richard
    Bilodeau, Mark T.
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (05) : 2708 - 2719
  • [3] Modulating the Epigenetic Machinery for Increased SSTR2 Expression in Small-Cell Lung Cancer Cells
    Klomp, M. J.
    Hofland, L. J.
    van den Brink, L.
    van Koetsveld, P. M.
    de Jong, M.
    Dalm, S. U.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 49 (SUPPL 1) : S57 - S57
  • [4] Albumin binders: a potential strategy for enhanced treatment of NETs using SSTR2 antagonists
    Koustoulidou, Sofia
    Handula, Maryana
    Nonnekens, Julie
    De Jong, Marion
    Seimbille, Yann
    NUCLEAR MEDICINE AND BIOLOGY, 2022, 108 : S191 - S192
  • [5] SSTR2 Receptor Expression Increased in Recurrent and Metastatic Hurthle Cell Carcinoma: Implications for Treatment
    Gonzalez, Manuel Lora
    Wang, Dezhi
    Guenter, Rachael
    Zheng-Pywell, Rui
    Rose, J. Bart
    Jaskula-Sztul, Renata
    Lloyd, Ricardo
    Lin, Diana
    LABORATORY INVESTIGATION, 2022, 102 (SUPPL 1) : 887 - 887
  • [6] Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer
    Whalen, Kerry A.
    White, Brian H.
    Quinn, James M.
    Kriksciukaite, Kristina
    Alargova, Rossitza
    Yeung, Tsun P. Au
    Bazinet, Patrick
    Brockman, Adam
    DuPont, Michelle M.
    Oller, Haley
    Gifford, James
    Lemelin, Charles-Andre
    Soo, Patrick Lim
    Perino, Samantha
    Moreau, Benoit
    Sharma, Gitanjali
    Shinde, Rajesh
    Sweryda-Krawiec, Beata
    Bilodeau, Mark T.
    Wooster, Richard
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (11) : 1926 - 1936
  • [7] Epigenetic-Like Stimulation of Receptor Expression in SSTR2 Transfected HEK293 Cells as a New Therapeutic Strategy
    Kotzerke, Joerg
    Buesser, Dorothee
    Naumann, Anne
    Runge, Roswitha
    Huebinger, Lisa
    Kliewer, Andrea
    Freudenberg, Robert
    Brogsitter, Claudia
    CANCERS, 2022, 14 (10)
  • [8] Characterizing SSTR2 expression and modulation for targeted imaging and therapy in preclinical models of triple-negative breast cancer
    Lynch, Shannon E.
    Crawford, Corinne I.
    Houson, Hailey A.
    Omweri, James M.
    Pukkanasut, Piyasuda
    Gallegos, Carlos A.
    Whitt, Jason D.
    Jaskula-Sztul, Renata
    Lapi, Suzanne E.
    Sorace, Anna G.
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [9] TREATMENT OF ADVANCED HEPATOCARCINOMA (HCC) WITH LONG ACTING OCTREOTIDE IN PATIENTS WITH TUMORAL EXPRESSION OF SSTR2 RECEPTORS
    De Santis, A.
    Trapani, S.
    Gigliotti, F.
    Cristofari, F.
    Giubilo, F.
    Iegri, C.
    Massa, R.
    Muda, A. Onetti
    Attili, A. F.
    DIGESTIVE AND LIVER DISEASE, 2008, 40 : S34 - S35
  • [10] SSTR2 Receptor Expression Increased in Recurrent and Metastatic H.rthle Cell Carcinoma: Implications for Treatment
    Gonzalez, Manuel Lora
    Wang, Dezhi
    Guenter, Rachael
    Zheng-Pywell, Rui
    Rose, J. Bart
    Jaskula-Sztul, Renata
    Lloyd, Ricardo
    Lin, Diana
    MODERN PATHOLOGY, 2022, 35 (SUPPL 2) : 887 - 887