Characterization of emm types and superantigens of Streptococcus pyogenes isolates from children during two sampling periods

被引：25
|
作者：
Ma, Y. [1 ]
Yang, Y. [1 ]
Huang, M. [2 ]
Wang, Y. [3 ]
Chen, Y. [4 ]
Deng, L. [5 ]
Yu, S. [1 ]
Deng, Q. [5 ]
Zhang, H. [2 ]
Wang, C. [3 ]
Liu, L. [4 ]
Shen, X. [1 ]
机构：
[1] Capital Med Univ, Beijing Childrens Hosp, Beijing 100045, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Shanghai 200030, Peoples R China
[3] Fudan Univ, Childrens Hosp, Shanghai 200433, Peoples R China
[4] Chongqing Med Univ, Chongqing Childrens Hosp, Chongqing, Peoples R China
[5] Guangzhou Childrens Hosp, Guangzhou, Guangdong, Peoples R China
来源：
EPIDEMIOLOGY AND INFECTION | 2009年 / 137卷 / 10期
关键词：
emm typing; epidemiology; Streptococcus pyogenes; superantigen; GROUP-A STREPTOCOCCI; ACUTE RHEUMATIC-FEVER; EPIDEMIOLOGIC ANALYSIS; MOLECULAR CHARACTERIZATION; ANTIBIOTIC-RESISTANCE; INVASIVE INFECTIONS; DISEASE EPISODES; PHARYNGITIS; SURVEILLANCE; REEMERGENCE;
D O I：
10.1017/S0950268809002118
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The characteristics of 359 group A streptococcal (GAS) isolates collected from Chinese paediatric patients in two periods (1993-1994, 2005-2006) were studied. Isolates were assigned to emm types and assayed for eight superantigen (SAg) genes (speA, speC, speH, speI, speG, speJ, ssa, SMEZ). Types emm1 and emm12 were consistently the most prevalent during the two periods, while others varied in frequency. GAS isolates carrying six or more SAg genes increased from 46.53% (1993-1994) to 78.39% (2005-2006); ssa, speH and speJ genes (P < 0.05) increased but speA declined (P < 0.05). SAg gene profiles were closely associated with the emm type, but strains of the same emm type sometimes carried different SAg genes in the two periods. No significant difference in emm-type distribution and SAg gene profile was noted between isolates from different diseases. These data may contribute towards the development of a GAS vaccine in China.
引用
收藏
页码：1414 / 1419
页数：6
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