POLAR MAPPER: a computational tool for integrated visualization of protein interaction networks and mRNA expression data

被引：10

作者：

Goncalves, Joana P. ^{[1
,2
,3
]}

Graos, Mario ^{[4
]}

Valente, Andre X. C. N. ^{[1
,5
]}

机构：

[1] Biocant, Unidade Sistemas Biol, P-3060197 Cantanhede, Portugal

[2] INESC ID, KDBIO Grp, P-1000029 Lisbon, Portugal

[3] Univ Tecn Lisboa, IST, P-1169047 Lisbon, Portugal

[4] Biocant, Unidade Biol Celular, P-3060197 Cantanhede, Portugal

[5] Univ Coimbra, Ctr Neurociencias & Biol Celular, P-3004517 Coimbra, Portugal

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2009年 / 6卷 / 39期

关键词：

protein interaction network; functional genomics; systems biology; ENDOPLASMIC-RETICULUM; SIGNALING PATHWAYS; LAYOUT ALGORITHM; SORTING NEXIN; CELL-CYCLE; YEAST; TRAFFICKING; BINDING; IDENTIFICATION; CENTRALITY;

D O I：

10.1098/rsif.2008.0407

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

POLAR MAPPER is a computational application for exposing the architecture of protein interaction networks. It facilitates the system-level analysis of mRNA expression data in the context of the underlying protein interaction network. Preliminary analysis of a human protein interaction network and comparison of the yeast oxidative stress and heat shock gene expression responses are addressed as case studies.

引用

页码：881 / 896

页数：16

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