Successful rituximab treatment of refractory hemophagocytic lymphohistiocytosis and autoimmune hemolytic anemia associated with systemic lupus erythematosus

被引：16

作者：

So, Min Wook ^{[1
]}

Koo, Bon San ^{[1
]}

Kim, You Jae ^{[1
]}

Kim, Yong-Gil ^{[1
]}

Lee, Chang-Keun ^{[1
]}

Yoo, Bin ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Div Rheumatol,Dept Internal Med, Seoul, South Korea

来源：

MODERN RHEUMATOLOGY | 2014年 / 24卷 / 05期

关键词：

Hemophagocytic lymphohistiocytosis; Systemic lupus erythematosus; Rituximab; Refractory; DISEASES; THERAPY; PATIENT;

D O I：

10.3109/14397595.2013.874740

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High-dose steroids, immunosuppressants such as cyclophosphamide and cyclosporine, and high-dose intravenous immunoglobulin have all been used to control hemophagocytic lymphohistiocytosis (HLH) or autoimmune hemolytic anemia (AIHA) associated with systemic lupus erythematosus (SLE); however, some patients are refractory to treatment. Rituximab has successfully resolved many of the refractory manifestations of SLE. Here, we report a case of HLH and AIHA associated with SLE that was refractory or intolerable to conventional therapy, but was successfully treated with rituximab.

引用

页码：855 / 857

页数：3

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