A direct lithiation route to 2-acyl-1-(phenylsulfonyl)indoles

被引：8
|
作者：
Jiang, J [1 ]
Gribble, GW [1 ]
机构：
[1] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA
来源：
SYNTHETIC COMMUNICATIONS | 2002年 / 32卷 / 13期
基金：
美国国家卫生研究院;
关键词：
2-acylindoles; 2-lithioindoles; acylation; lithiation; carboxylic acid anhydrides;
D O I：
10.1081/SCC-120004854
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Acyl-1-(phenylsulfonyl)indoles (3, 7-9) are prepared in 75-84% yield from 1-(phenylsulfonyl)indoles (1, 5) in one operation by treatment of the latter with s-butyllithium followed by inverse quenching of the C-2 lithioindoles with carboxylic acid anhydrides (6).
引用
收藏
页码：2035 / 2040
页数：6
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