High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany

被引：27

作者：

Reinert, RR ^{[1
]}

Lütticken, R ^{[1
]}

Al-Lahham, A ^{[1
]}

机构：

[1] Univ Hosp, Natl Reference Ctr Streptococci, Inst Med Microbiol, D-52057 Aachen, Germany

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2004年 / 10卷 / 07期

关键词：

Emm typing; fluoroquinolone resistance; multilocus sequence typing; resistance; Streptococcus pyogenes;

D O I：

10.1111/j.1469-0691.2004.00890.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

An isolate of Streptococcus pyogenes isolated from a 63-year-old woman with a serious wound infection was found to be highly resistant to fluoroquinolones (levofloxacin MIC greater than or equal to 32 mg/L). DNA amplification and sequencing revealed a serine-81 to phenylalanine substitution in gyrA and three substitutions in parC: serine-79 to phenylalanine, aspartic acid-91 to asparagine, and serine-140 to proline. To our knowledge, this is the first report from a European country of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.

引用

页码：659 / 662

页数：5

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