Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

被引：9
|
作者：
Lin, Jiao [1 ]
Ni, Guangcheng [1 ]
Ding, Tingting [1 ]
Lei, Shangxue [1 ]
Zhong, Liang [1 ]
Liu, Na [1 ]
Pan, Keran [1 ]
Chen, Ting [1 ]
Zeng, Xin [1 ]
Xu, Hao [1 ]
Li, Taiwen [1 ]
Dan, Hongxia [1 ]
机构：
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis,Natl Clin Res Ctr Oral Dis, Chinese Acad Med Sci,Res Unit Oral Carcinogenesis, Chengdu 610041, Sichuan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHOTOENERGY | 2021年 / 2021卷
基金：
中国国家自然科学基金;
关键词：
EARLY-STAGE HEAD; PHASE-1; TRIAL; NECK; MTHPC; PHOTOFRIN; CANCER; CAVITY; TUMORS; OUTCOMES;
D O I：
10.1155/2021/6641358
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
To assess the efficacy of photodynamic therapy (PDT) for oral squamous cell carcinoma (OSCC), literature on this topic from Embase, PubMed, and Web of Science were obtained and analyzed. The response and recurrence rates with 95% confidence intervals (CI) were calculated using the DerSimonia-Laird method. The pooled complete response (CR) rate from the included studies was 0.799 (95% CI: 0.708-0.867), while the overall response (OR) rate was 0.967 (95% CI: 0.902-0.989). The recurrence rate (RR) was 0.158 (95% CI: 0.090-0.264). A subgroup analysis of lesion site, photosensitizer, laser type, radiant exposure, and power density revealed no statistically significant differences. In general, PDT is effective for the treatment of early OSCC. Investigations on the influence of PDT on the survival of OSCC patients, optimization of the treatment regimen, and evaluation of response after treatment are still needed.
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页数：14
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