Toxoplasma gondii infection and cerebral toxoplasmosis in HIV-infected patients

被引：99

作者：

Pereira-Chioccola, Vera Lucia ^{[1
]}

Vidal, Jose Ernesto ^{[2
,3
]}

Su, Chunlei ^{[4
]}

机构：

[1] Adolfo Lutz Inst, Parasitol Lab, BR-01246902 Sao Paulo, Brazil

[2] Inst Infectol Emilio Ribas, Dept Neurol, BR-05411000 Sao Paulo, Brazil

[3] Univ Sao Paulo, Div Molestias Infecciosas & Parasitarias, Serv Extensao Ao Atendimento Pacientes HIV AIDS, Fac Med,Hosp Clin, Sao Paulo, Brazil

[4] Univ Tennessee, Dept Microbiol, Knoxville, TN 37996 USA

来源：

FUTURE MICROBIOLOGY | 2009年 / 4卷 / 10期

基金：

巴西圣保罗研究基金会;

关键词：

AIDS; cerebral toxoplasmosis; diagnosis; genotyping; review; Toxoplasma gondii; POLYMERASE-CHAIN-REACTION; REAL-TIME PCR; EXCRETED-SECRETED ANTIGENS; FREE-RANGE CHICKENS; HOST-CELL INVASION; AIDS PATIENTS; CONGENITAL TOXOPLASMOSIS; CEREBROSPINAL-FLUID; HIGH PREVALENCE; GENETIC-CHARACTERIZATION;

D O I：

10.2217/FMB.09.89

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cerebral toxoplasmosis is a major cause of morbidity and mortality among HIV-infected patients, particularly from developing countries. This article summarizes current literature on cerebral toxoplasmosis. It focuses on: Toxoplasma gondii genetic diversity and its possible relationship with disease presentation; host responses to the parasite antigens; host immunosupression in HIV and cerebral toxoplasmosis as well as different diagnostic methods; clinical and radiological features; treatment; and the direction that studies on cerebral toxoplasmosis will likely take in the future.

引用

页码：1363 / 1379

页数：17