Circulating metabolites are associated with brain atrophy and white matter hyperintensities

被引：13

作者：

de Leeuw, Francisca A. ^{[1
]}

Karamujic-Comic, Hata ^{[2
]}

Tijms, Betty M. ^{[1
]}

Peeters, Carel F. W. ^{[3
]}

Kester, Maartje I. ^{[4
]}

Scheltens, Philip ^{[1
]}

Ahmad, Shahzad ^{[2
]}

Vojinovic, Dina ^{[2
]}

Adams, Hieab H. H. ^{[5
,6
]}

Hankemeier, Thomas ^{[2
,7
,8
]}

Bos, Daniel ^{[2
,5
]}

van der Lugt, Aad ^{[5
]}

Vernooij, Meike W. ^{[2
,5
]}

Ikram, M. Arfan ^{[2
]}

Amin, Najaf ^{[2
]}

Barkhof, Frederik ^{[9
,10
,11
]}

Teunissen, Charlotte E. ^{[12
]}

van Duijn, Cornelia M. ^{[2
,13
,14
]}

van der Flier, Wiesje M. ^{[1
,3
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands

[2] Erasmus MC, Dept Epidemiol, Doctor Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands

[3] Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[4] Flevoziekenhuis, Dept Neurol, Almere, Netherlands

[5] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[6] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

[7] Leiden Univ, Leiden Acad Ctr Drug Res, Fac Sci, Div Analyt Biosci, Leiden, Netherlands

[8] Leiden Univ, Translat Epidemiol, Fac Sci, Leiden, Netherlands

[9] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[10] UCL London, Inst Neurol, London, England

[11] UCL London, Inst Healthcare Engn, London, England

[12] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Neurochem Lab,Dept Clin Chem, Amsterdam, Netherlands

[13] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

[14] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England

来源：

ALZHEIMERS & DEMENTIA | 2021年 / 17卷 / 02期

基金：

荷兰研究理事会; 欧盟地平线“2020”;

关键词：

Alzheimer's disease; cholesterol; glucose; lipids; magnetic resonance imaging (MRI); metabolism;

D O I：

10.1002/alz.12180

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

引用

页码：205 / 214

页数：10

共 50 条

[1] Associations of circulating metabolites with cerebral white matter hyperintensities
Sun, Yan
Guo, Yu
Li, Hong-Qi
Tan, Lan
Feng, Jian-Feng
Cheng, Wei
Yu, Jin-Tai
[J]. JOURNAL OF NEUROCHEMISTRY, 2023, 166 (02) : 414 - 423
[2] Topographic correspondence between white matter hyperintensities and brain atrophy
Rossi, R
Boccardi, M
Sabattoli, F
Galluzzi, S
Alaimo, G
Frisoni, GB
[J]. INTERNATIONAL PSYCHOGERIATRICS, 2005, 17 : 153 - 154
[3] Topographic correspondence between white matter hyperintensities and brain atrophy
R. Rossi
M. Boccardi
F. Sabattoli
S. Galluzzi
G. Alaimo
C. Testa
G. B. Frisoni
[J]. Journal of Neurology, 2006, 253 : 919 - 927
[4] Topographic correspondence between white matter hyperintensities and brain atrophy
Rossi, R.
Boccardi, M.
Sabattoli, F.
Galluzzi, S.
Alaimo, G.
Testa, C.
Frisoni, G. B.
[J]. JOURNAL OF NEUROLOGY, 2006, 253 (07) : 919 - 927
[5] White Matter Hyperintensities are Associated with Disproportionate Progressive Hippocampal Atrophy
Fiford, Cassidy M.
Manning, Emily N.
Bartlett, Jonathan W.
Cash, David M.
Malone, Ian B.
Ridgway, Gerard R.
Lehmann, Manja
Leung, Kelvin K.
Sudre, Carole H.
Ourselin, Sebastien
Biessels, Geert Jan
Carmichael, Owen T.
Fox, Nick C.
Cardoso, M. Jorge
Barnes, Josephine
[J]. HIPPOCAMPUS, 2017, 27 (03) : 249 - 262
[6] Shorter telomere length is linked to brain atrophy and white matter hyperintensities
Wikgren, Mikael
Karlsson, Thomas
Soderlund, Hedvig
Nordin, Annelie
Roos, Goran
Nilsson, Lars-Goran
Adolfsson, Rolf
Norrback, Karl-Fredrik
[J]. AGE AND AGEING, 2014, 43 (02) : 212 - 217
[7] Associations of microalbuminuria with brain atrophy and white matter hyperintensities in hypertensive sibships
Knopman, David S.
Mosley, Thomas H., Jr.
Bailey, Kent R.
Jack, Clifford R., Jr.
Schwartz, Gary L.
Turner, Stephen T.
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2008, 271 (1-2) : 53 - 60
[8] Brain Atrophy and White Matter Hyperintensities in Early Parkinson's Disease
Dalaker, Turi O.
Larsen, Jan P.
Bergsland, Niels
Beyer, Mona K.
Alves, Guido
Dwyer, Michael G.
Tysnes, Ole-Bjorn
Benedict, Ralph H. B.
Kelemen, Arpad
Bronnick, Kolbjorn
Zivadinov, Robert
[J]. MOVEMENT DISORDERS, 2009, 24 (15) : 2233 - 2241
[9] White matter hyperintensities in multiple system atrophy
Umoto, M.
Ando, R.
Miwa, H.
Kondo, T.
[J]. MOVEMENT DISORDERS, 2011, 26 : S253 - S254
[10] Associations of cognition with brain atrophy and white matter hyperintensities in a large biracial cohort
Knopman, DS
Mosley, TH
Bailey, KR
Jack, CR
Shiung, MM
Stoner, S
de Andrade, M
Turner, ST
[J]. NEUROLOGY, 2006, 66 (05) : A181 - A182

← 1 2 3 4 5 →