One-pot synthesis of amphiphilic superparamagnetic FePt nanoparticles and magnetic resonance imaging in vitro

Monodispersed amphiphilic FePt nanoparticles with the diameter of about 4 nm were synthesized by high temperature pyrolysis of iron(III) acetylacetonate and platinum(II) acetylacetonate. Their amphiphilicity is contributed to the tetraethylene glycol (TEG) and oleic acid (OA) on the surface, which is confirmed by FTIR and XPS spectra. They provide a superparamagnetic property with the saturation magnetization (Ms) of about 25 emu/g and the transverse relaxivity (r(2)) of about 122.6 mM(-1) s(-1) in aqueous solutions. Furthermore, FePt nanoparticles show low cytotoxicity in living cells. They can be uptaken by HeLa cells effectively and result in the obvious decrease of T-2 relaxation time after internalization. (C) 2009 Elsevier B.V. All rights reserved.