Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers

被引：93
|
作者：
Wang, Yufei [1 ]
Broderick, Peter [1 ]
Matakidou, Athena [1 ]
Eisen, Timothy [2 ]
Houlston, Richard S. [1 ]
机构：
[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England
[2] Univ Cambridge, Dept Oncol, Cambridge CB2 2RE, England
来源：
CARCINOGENESIS | 2010年 / 31卷 / 02期
关键词：
GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCUS; DISEASE; VARIANTS; GENE;
D O I：
10.1093/carcin/bgp287
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Genome-wide association studies have provided evidence that common variation at 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) influences lung cancer risk. To examine if variation at any of these loci influences the risk of lung cancer in never-smokers, we compared 5p15.33-TERT (rs2736100), 5p15.33-CLPTM1L (rs4975616), 6p21.33-BAT3 (rs3117582), 15q25.1-CHRNA3 (rs8042374) and 15q25.1-CHRNA3 (rs12914385) genotypes in a series of 239 never-smoker lung cancer cases and 553 never-smoker controls. A statistically significant association between lung cancer risk and 5p15.33 genotypes was found: rs2736100 (odds ratio = 0.78, 95% confidence interval: 0.63-0.97; P = 0.02), rs4975616 (odds ratio = 0.69, 95% confidence interval: 0.55-0.85; P = 7.95 x 10(-4)), primarily for adenocarcinoma. There was no evidence of association between 6p21.33 or 15q25.1 variation and risk of lung cancer. This analysis provides evidence that TERT-CLPTM1L variants may influence the risk of lung cancer outside the context of tobacco smoking.
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收藏
页码：234 / 238
页数：5
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