The use of coal-based F-T diesel in automobiles can alleviate the shortage of petroleum and promote clean utilization of coal. In this study, the effects of injection timing and rail pressure on the emissions of NOx, soot, and UFPs from F-T diesel and petro-diesel were investigated in a common rail DI engine under a constant speed and various loads. The rail pressures are selected as 70 MPa and 100 MPa, whereas the injection timings are regulated at 2 degrees CA, 6 degrees CA, 10 degrees CA, 14 degrees CA, and 18 degrees CA BTDC. Experimental results indicate that advancing the injection timing or increasing the rail pressure shall result in higher NOx and lower soot emissions. When the fuel injection timing was advanced from 2 degrees CA to 18 degrees CA BTDC, the number concentration of UFPs first decreased and then increased at low loads, whereas the number concentration of UFPs always decreased at medium and high loads, the peak number concentration transferred from the size range of accumulation mode particles to that of nucleation mode particles, and the geometric mean diameters of UFPs emitted by the F-T diesel and petro-diesel reduced by an average of 23.4% and 26.19% under different test conditions, respectively. In addition, when the rail pressure was increased from 70 MPa to 100 MPa, the number concentration of UFPs of F-T diesel and petro-diesel decreased by 39.78% and 53.75%, and their geometric mean diameters of UFPs decreased by 14.09% and 12.5%, respectively. Compared to petro-diesel, F-T diesel has a lower number concentration of UFPs, smaller geometric mean diameter of UFPs, and a higher ratio of nucleation mode particles. With regard to the lowest number concentration of UFPs, when coal-based F-T diesel is used, the injection timing of the original engine can be advanced by 4-8 degrees CA at low loads. (C) 2020 Energy Institute. Published by Elsevier Ltd. All rights reserved.