Plasmodium sporozoite invasion of the mosquito salivary gland

被引:43
|
作者
Ghosh, Anil Kumar [1 ]
Jacobs-Lorena, Marcelo [1 ]
机构
[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Malaria Res Inst, Baltimore, MD 21205 USA
基金
美国国家卫生研究院;
关键词
CIRCUMSPOROZOITE PROTEIN; MALARIA PARASITE; GLIDING MOTILITY; AEDES-AEGYPTI; REGION-I; INFECTIVITY; ANTIBODIES; JOURNEY; IDENTIFICATION; TRANSCRIPTOME;
D O I
10.1016/j.mib.2009.06.010
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
About one to two million people die of malaria every year. Anopheline mosquitoes are the obligatory vectors of Plasmodium spp., the causative agent of malaria. For transmission to occur, the parasite has to undergo a complex developmental programme in the mosquito, culminating with sporozoite invasion of the salivary glands. Strong circumstantial evidence suggests that sporozoite invasion requires specific interactions and recognition between sporozoite and salivary gland proteins. Here we review recent progress towards the elucidation of invasion mechanisms.
引用
收藏
页码:394 / 400
页数:7
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