Interleukin-1 Gene-511 CT Polymorphism and the Risk of Alzheimer's Disease in a Polish Population

被引：13
|
作者：
Klimkowicz-Mrowiec, A. [1 ,2 ]
Marona, M. [1 ]
Wolkow, P. [3 ]
Maruszak, A. [4 ]
Styczynska, M. [4 ]
Barcikowska, M. [4 ]
Zekanowski, C. [4 ]
Szczudlik, A. [1 ]
Slowik, A. [1 ]
机构：
[1] Jagiellonian Univ, Dept Neurol, Sch Med, PL-31503 Krakow, Poland
[2] Jagiellonian Univ, Sch Med, Dept Neurol, Univ Hosp, PL-31503 Krakow, Poland
[3] Jagiellonian Univ, Sch Med, Dept Pharmacol, PL-31503 Krakow, Poland
[4] Polish Acad Sci, Med Res Ctr, Dept Neurodegenerat Disorders, Warsaw, Poland
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2009年 / 28卷 / 05期
关键词：
Alzheimer's disease; Interleukin-1; Polymorphism; Risk factor; Polish population; ASSOCIATION; ONSET; IL-1-ALPHA; IL-1-BETA; DEMENTIA; BETA;
D O I：
10.1159/000259460
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Interleukin-1 is a potent proinflammatory cytokine involved in the pathophysiology of Alzheimer's disease (AD). We genotyped IL-1 beta (-511 C/T) and the apolipoprotein E (APOE) common polymorphisms in a large case-controlled study in a Polish population. We included 332 patients with late-onset AD and 220 controls without any neurological deficit, cognitive complaints and history of neurological diseases, aged >= 65 years. The distribution of the IL-1 beta (-511 C/T) genotypes was similar to that in the controls (AD: C/C = 45.8%, C/T = 44.6%, T/T = 9.6% vs. controls: C/C = 53.9%, C/T = 38.3%, T/T = 7.3%, p > 0.05). Our study confirms previous reports that APOE epsilon 4 is strongly related to the risk of AD (odds ratio = 6.60, 95% confidence interval 4.19-10.41). APOE status did not affect the distribution of the studied IL-1 beta polymorphism. The IL-1 beta (-511 C/T) polymorphism is not a risk factor for late-onset AD in a Polish population. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：461 / 464
页数：4
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