18-MC reduces methamphetamine and nicotine self-administration in rats

被引：45
|
作者：
Glick, SD [1 ]
Maisonneuve, IM [1 ]
Dickinson, HA [1 ]
机构：
[1] Albany Med Coll, Ctr Neuropharmacol & Neurosci, Albany, NY 12208 USA
来源：
NEUROREPORT | 2000年 / 11卷 / 09期
关键词：
addiction; drug self-administration; ibogaine; methamphetamine; 18-methoxycoronaridine; nicotine;
D O I：
10.1097/00001756-200006260-00041
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In previous studies, 18-methoxycoronaridine (18-MC), a novel iboga alkaloid congener, has been found to decrease the intravenous self-administration of morphine and cocaine in rats. In the present study, 18-MC (1-40 mg/kg, i.p.) dose-dependently decreased the i.v. self-administration of methamphetamine and nicotine. As in the previous studies, drug self-administration was reduced for greater than or equal to 24 h after the highest dose of 18-MC. A comparison of 18-MC's interactions with all four drugs of abuse studied so far indicated that 18-MC is least effective in decreasing methamphetamine self-administration and most potent in decreasing nicotine self-administration. The results suggest that a nicotinic antagonist action of 18-MC contributes to its putative anti-addictive efficacy. NeuroReport 11:2013-2015 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：2013 / 2015
页数：3
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