Long working hours and cancer risk: a multi-cohort study

被引：11

作者：

Heikkila, Katriina ^{[1
,2
,3
]}

Nyberg, Solja T. ^{[2
,3
]}

Madsen, Ida E. H. ^{[4
]}

de Vroome, Ernest ^{[5
]}

Alfredsson, Lars ^{[6
,7
]}

Bjorner, Jacob J. ^{[4
]}

Borritz, Marianne ^{[8
]}

Burr, Hermann ^{[9
]}

Erbel, Raimund ^{[10
]}

Ferrie, Jane E. ^{[11
,12
]}

Fransson, Eleonor I. ^{[7
,13
,14
]}

Geuskens, Goedele A. ^{[5
]}

Hooftman, Wendela E. ^{[5
]}

Houtman, Irene L. ^{[5
]}

Joeckel, Karl-Heinz ^{[15
]}

Knutsson, Anders ^{[16
]}

Koskenvuo, Markku ^{[17
]}

Lunau, Thorsten ^{[18
]}

Nielsen, Martin L. ^{[19
]}

Nordin, Maria ^{[14
,20
]}

Oksanen, Tuula ^{[2
,3
]}

Pejtersen, Jan H. ^{[21
]}

Pentti, Jaana ^{[2
,3
]}

Shipley, Martin J. ^{[11
]}

Steptoe, Andrew ^{[11
]}

Suominen, Sakari B. ^{[22
,23
,24
]}

Theorell, Toeres ^{[14
]}

Vahtera, Jussi ^{[2
,3
,22
,25
]}

Westerholm, Peter J. M. ^{[26
]}

Westerlund, Hugo ^{[14
]}

Dragano, Nico ^{[18
]}

Rugulies, Reiner ^{[4
,27
,28
]}

Kawachi, Ichiro ^{[29
]}

Batty, G. David ^{[11
,30
]}

Singh-Manoux, Archana ^{[11
,31
]}

Virtanen, Marianna ^{[2
,3
]}

Kivimaki, Mika ^{[2
,3
,11
,32
]}

机构：

[1] London Sch Hyg & Trop Med, Dept Hlth Serv Res & Policy, London WC1, England

[2] Finnish Inst Occupat Hlth, Tampere 33100, Finland

[3] Finnish Inst Occupat Hlth, Turku 205200, Finland

[4] Natl Res Ctr Working Environm, DK-2100 Copenhagen, Denmark

[5] TNO, NL-2316 ZL Leiden, Netherlands

[6] Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden

[7] Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden

[8] Koge Hosp, DK-4600 Koge, Denmark

[9] Fed Inst Occupat Safety & Hlth, D-10317 Berlin, Germany

[10] Univ Duisburg Essen, West German Heart Ctr Essen, Dept Cardiol, D-45122 Essen, Germany

[11] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England

[12] Univ Bristol, Sch Social & Community Med, Bristol BS8 2PS, Avon, England

[13] Jonkoping Univ, Sch Hlth & Welf, SE-55111 Jonkoping, Sweden

[14] Stockholm Univ, Stress Res Inst, SE-10691 Stockholm, Sweden

[15] Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, Fac Med, D-45122 Essen, Germany

[16] Mid Sweden Univ, Dept Hlth Sci, S-85170 Sundsvall, Sweden

[17] Univ Helsinki, Dept Publ Hlth, Helsinki 00140, Finland

[18] Univ Dusseldorf, Fac Med, Inst Med Sociol, D-40225 Dusseldorf, Germany

[19] Frederiksberg Univ Hosp, Unit Social Med, DK-2000 Frederiksberg, Denmark

[20] Umea Univ, Dept Psychol, S-90187 Umea, Sweden

[21] Danish Natl Ctr Social Res, DK-1052 Copenhagen, Denmark

[22] Univ Turku, Dept Publ Hlth, Turku 20014, Finland

[23] Folkhalsan Res Ctr, Helsinki 00290, Finland

[24] Nord Sch Publ Hlth, S-42671 Gothenburg, Sweden

[25] Turku Univ Hosp, Turku 20521, Finland

[26] Uppsala Univ, Occupat & Environm Med, S-75185 Uppsala, Sweden

[27] Univ Copenhagen, Dept Publ Hlth, DK-2200 Copenhagen, Denmark

[28] Univ Copenhagen, Dept Psychol, DK-2200 Copenhagen, Denmark

[29] Harvard Univ, Sch Publ Hlth, Dept Soc Human Dev & Hlth, 665 Huntington Ave, Boston, MA 02115 USA

[30] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

[31] INSERM, U1018, Ctr Res Epidemiol & Populat Hlth, F-94807 Villejuif, France

[32] Univ Helsinki, Fac Med, Clinicum, FI-00014 Helsinki, Finland

来源：

BRITISH JOURNAL OF CANCER | 2016年 / 114卷 / 07期

基金：

英国经济与社会研究理事会; 美国国家卫生研究院; 瑞典研究理事会; 芬兰科学院; 英国医学研究理事会;

关键词：

Breast cancer; colorectal cancer; lung cancer; prostate cancer; working hours; CORONARY-HEART-DISEASE; NIGHT-SHIFT WORK; BREAST-CANCER; JOB STRAIN; UNPUBLISHED DATA; METAANALYSIS; STROKE; BIRTH; MEN;

D O I：

10.1038/bjc.2016.9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear. Methods: This multi-cohort study examined the association between working hours and cancer risk in 116 462 men and women who were free of cancer at baseline. Incident cancers were ascertained from national cancer, hospitalisation and death registers; weekly working hours were self-reported. Results: During median follow-up of 10.8 years, 4371 participants developed cancer (n colorectal cancer: 393; n lung cancer: 247; n breast cancer: 833; and n prostate cancer: 534). We found no clear evidence for an association between working hours and the overall cancer risk. Working hours were also unrelated the risk of incident colorectal, lung or prostate cancers. Working >= 55 h per week was associated with 1.60-fold (95% confidence interval 1.12-2.29) increase in female breast cancer risk independently of age, socioeconomic position, shift-and night-time work and lifestyle factors, but this observation may have been influenced by residual confounding from parity. Conclusions: Our findings suggest that working long hours is unrelated to the overall cancer risk or the risk of lung, colorectal or prostate cancers. The observed association with breast cancer would warrant further research.

引用

页码：813 / 818

页数：6

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