[1] Tohoku Univ, Dept Endocrinol & Appl Med Sci, Grad Sch Pharmaceut Sci & Med, Sendai, Miyagi 980, Japan
[2] Tohoku Univ, Dept Mol Biol & Appl Physiol, Grad Sch Pharmaceut Sci & Med, Sendai, Miyagi 980, Japan
[3] Tohoku Univ, Dept Med, Grad Sch Pharmaceut Sci & Med, Grad Sch Med, Sendai, Miyagi 980, Japan
[4] Tohoku Univ, Dept Clin Pharmacol & Therapeut, Grad Sch Pharmaceut Sci & Med, Sendai, Miyagi 980, Japan