Short enantioselective total synthesis of (+)-tofacitinib

被引：3
|
作者：
Mane, Kishor D. [1 ,2 ]
Kamble, Rohit B. [1 ,2 ]
Suryavanshi, Gurunath [1 ,2 ]
机构：
[1] Natl Chem Lab, CSIR, Chem Engn & Proc Dev Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
[2] Acad Sci & Innovat Res, Ghaziabad 201002, India
来源：
TETRAHEDRON LETTERS | 2021年 / 67卷
关键词：
L-Proline; Piperidone; Aminohydroxylation; Hydrogenation; FORMAL ASYMMETRIC-SYNTHESIS; ALPHA-AMINOXYLATION; KINASE; INHIBITION; ALDEHYDES;
D O I：
10.1016/j.tetlet.2021.152838
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantioselective total synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor has been achieved from the readily available 4-piperidone. Proline catalysed hydroxylation is the key step for the synthesis of enantiopure 1-benzyl-4-methylpiperidin-3-ol. (C) 2021 Elsevier Ltd. All rights reserved.
引用
下载
收藏
页数：3
相关论文
共 50 条
  • [1] A short enantioselective total synthesis of (-)-linderol A
    Berber, Hatice
    Delaye, Pierre-Olivier
    Mirand, Catherine
    SYNLETT, 2008, (01) : 94 - 96
  • [2] A Short Enantioselective Total Synthesis of (-)-Englerin A
    Zahel, Martin
    Kessberg, Anton
    Metz, Peter
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (20) : 5390 - 5392
  • [3] Short, enantioselective total synthesis of Stephacidin A
    Baran, PS
    Guerrero, CA
    Ambhaikar, NB
    Hafensteiner, BD
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (04) : 606 - 609
  • [4] Short, Enantioselective Total Synthesis of Chatancin
    Zhao, Yu-Ming
    Maimone, Thomas J.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (04) : 1223 - 1226
  • [5] Short, enantioselective total synthesis of okaramine N
    1600, American Chemical Society (125):
  • [6] Short, enantioselective total synthesis of okaramine N
    Baran, PS
    Guerrero, CA
    Corey, EJ
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (19) : 5628 - 5629
  • [7] A short enantioselective total synthesis of dammarenediol II
    Corey, EJ
    Lin, SZ
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (36) : 8765 - 8766
  • [8] Short enantioselective total synthesis of dammarenediol II
    Corey, E.J.
    Lin, Shouzong
    Journal of the American Chemical Society, 1996, 118 (36):
  • [9] Short, Enantioselective Total Synthesis of Highly Oxidized Taxanes
    Yuan, Changxia
    Jin, Yehua
    Wilde, Nathan C.
    Baran, Phil S.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (29) : 8280 - 8284
  • [10] Asymmetric total synthesis of Tofacitinib
    Marican, Adolfo
    Simirgiotis, Mario J.
    Santos, Leonardo S.
    TETRAHEDRON LETTERS, 2013, 54 (37) : 5096 - 5098
12345