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Quantitative Measurement of Hepatic Fibrosis with Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Patients with Chronic Hepatitis B Infection: A Comparative Study on Aspartate Aminotransferase to Platelet Ratio Index and Fibrosis-4 Index
被引:9
|作者:
Lee, Guy Mok
[1
]
Kim, Youe Ree
[1
]
Ryu, Jong Hyun
[3
]
Kim, Tae-Hoon
[3
]
Cho, Eun Young
[2
]
Lee, Young Hwan
[1
]
Yoon, Kwon-Ha
[1
,3
]
机构:
[1] Wonkwang Univ, Sch Med, Dept Radiol, 460 Iksan Daero, Iksan 54538, South Korea
[2] Wonkwang Univ, Sch Med, Dept Internal Med, Iksan 54538, South Korea
[3] Wonkwang Univ, Imaging Sci Res Ctr, Iksan 54538, South Korea
关键词:
Liver;
Magnetic resonance imaging;
Chronic hepatitis B;
Fibrosis;
Gadoxetic acid;
Gd-EOB-DTPA;
ORGANIC ANION TRANSPORTERS;
CONJUGATE EXPORT PUMP;
LIVER FIBROSIS;
PARENCHYMAL ENHANCEMENT;
VIRUS INFECTION;
ARTERIAL-PHASE;
CIRRHOSIS;
PREDICT;
ELASTOGRAPHY;
CHOLESTASIS;
D O I:
10.3348/kjr.2017.18.3.444
中图分类号:
R8 [特种医学];
R445 [影像诊断学];
学科分类号:
1002 ;
100207 ;
1009 ;
摘要:
Objective: To quantitatively measure hepatic fibrosis on gadoxetic acid-enhanced magnetic resonance (MR) in chronic hepatitis B (CHB) patients and identify the correlations with aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 index (FIB-4) values. Materials and Methods: This study on gadoxetic acid-enhanced 3T MR imaging included 81 patients with CHB infection. To quantitatively measure hepatic fibrosis, MR images were analyzed with an aim to identify inhomogeneous signal intensities calculated from a coefficient of variation (CV) map in the liver parenchyma. We also carried out a comparative analysis between APRI and FIB-4 based on metaregression results. The diagnostic performance of the CV map was evaluated using a receiver-operating characteristic (ROC) curve. Results: In the MR images, the mean CV values in control, groups I, II, and III based on APRI were 4.08 +/- 0.92, 4.24 +/- 0.80, 5.64 +/- 1.11, and 5.73 +/- 1.28, respectively (p < 0.001). In CHB patients grouped by FIB-4, the mean CV values of groups A, B, and C were 4.22 +/- 0.95, 5.40 +/- 1.19, and 5.71 +/- 1.17, respectively (p < 0.001). The mean CV values correlated well with APRI (r = 0.392, p < 0.001) and FIB-4 (r = 0.294, p < 0.001). In significant fibrosis group, ROC curve analysis yielded an area under the curve of 0.875 using APRI and 0.831 using FIB-4 in HB, respectively. Conclusion: Gadoxetic acid-enhanced MR imaging for calculating a CV map showed moderate correlation with APRI and FIB-4 values and could be employed to quantitatively measure hepatic fibrosis in patients with CHB.
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页码:444 / 451
页数:8
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