HDL A molecule with a multi-faceted role in coronary artery disease

被引:27
|
作者
Arora, Sarika [1 ]
Patra, Surajeet K. [2 ]
Saini, Reetika [1 ]
机构
[1] ESI Postgrad Inst Med Sci & Res, Dept Biochem, New Delhi, India
[2] Lady Hardinge Med Coll & Hosp, Dept Biochem, New Delhi, India
关键词
High density lipoprotein; Coronary artery disease; Oxidized LDL; Antioxidant properties; Anti-inflammatory role; Apolipoprotein A1; Paraoxonase; 1; HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; REVERSE CHOLESTEROL TRANSPORT; PLATELET-ACTIVATING-FACTOR; CELL-ADHESION MOLECULE-1; ELEVATED OXIDATIVE STRESS; B TYPE-I; CYTOKINE-INDUCED EXPRESSION; SYNTHETIC PEPTIDE ANALOGS; SCAVENGER RECEPTOR-BI;
D O I
10.1016/j.cca.2015.10.021
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: High density lipoprotein cholesterol (HDL-C) is popularly known as "good cholesterol" due to its ability to protect against atherosclerosis. High density lipoprotein (HDL) is best known as a key player to promote efflux of cholesterol from cells and promote reverse cholesterol transport (RCT) which decreases the accumulation of foam cells in arterial walls. Several roles of HDL discovered recently include anti-oxidant effect, anti-inflammatory role, and anti-thrombotic role, all of which potentiate the athero-protective role of HDL. Method: Relevant articles published in this field in various books, journals and on the websites of PubMed Central and National Library of Medicine were assessed to create a literature review article. Result: Besides reverse cholesterol transport, the antioxidant and anti-inflammatory properties of HDL may also play a major role in protection against development of atherosclerosis. Two different scales define the atheroprotective effects of HDL quantity of HDL-C (measured in mg/deciliter or mmol/L) is inversely correlated with cardiovascular risk, the other is the quality or 'functionality' of HDL. Conclusion: The changes in HDL composition (primarily in protein components-apolipoproteins, paraoxonase etc.) can occur under pathological conditions and can affect the functionality of HDL. Thus, treatment alternatives to elevations in HDL-C must also involve strategies to maintain or enhance functionality of HDL. This literature review article discusses about the various athero-protective roles of HDL and the effects of changes in composition on its function. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:66 / 81
页数:16
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