Fragment-based drug discovery applied to heat shock protein 90 (HSP90)

被引:0
|
作者
Pathuri, Puja [1 ]
Chessari, Gianni [1 ]
Carr, Maria G. [1 ]
Congreve, Miles [1 ]
Coyle, Joseph E. [1 ]
Day, Philip J. [1 ]
Fazal, Lynsey [1 ]
Frederickson, Martyn [1 ]
Graham, Brent [1 ]
Lewis, Jonathan [1 ]
McMenamin, Rachel [1 ]
Murray, Christopher W. [1 ]
O'Brien, Alistair M. [1 ]
Patel, Sahil [1 ]
Williams, Glyn [1 ]
Woodhead, Andrew J. [1 ]
Woolford, Alison J. -A. [1 ]
机构
[1] Astex Therapeut Ltd, Cambridge CB4 0QA, England
关键词
drug; fragment; chaperone;
D O I
10.1107/S0108767311092415
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
MS16.P45
引用
收藏
页码:C303 / C303
页数:1
相关论文
共 50 条
  • [1] Drug discovery and research of heat shock protein 90 (Hsp90) inhibitor
    Soga, Shiro
    Nakashima, Takayuki
    Ishii, Toshihiko
    Shiotsu, Yukimasa
    Akinaga, Shiro
    [J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115 : 26P - 26P
  • [2] Fragment-based Identification of Hsp90 Inhibitors
    Barker, John J.
    Barker, Oliver
    Boggio, Roberto
    Chauhan, Viddhata
    Cheng, Robert K. Y.
    Corden, Vincent
    Courtney, Stephen M.
    Edwards, Neil
    Falque, Virginie M.
    Fusar, Fulvia
    Gardiner, Mihaly
    Hamelin, Estelle M. N.
    Hesterkamp, Thomas
    Ichihara, Osamu
    Jones, Richard S.
    Mather, Owen
    Mercurio, Ciro
    Minucci, Saverio
    Montalbetti, Christian A. G. N.
    Mueller, Annett
    Patel, Deepti
    Phillips, Banu G.
    Varasi, Mario
    Whittaker, Mark
    Winkler, Dirk
    Yarnold, Christopher J.
    [J]. CHEMMEDCHEM, 2009, 4 (06) : 963 - 966
  • [3] Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors
    Bhat, Rohit
    Tummalapalli, Sreedhar R.
    Rotella, David P.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (21) : 8718 - 8728
  • [4] Heat Shock Protein 90 (Hsp90) Preface
    Picard, Didier
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2012, 1823 (03): : 605 - 606
  • [5] Fragment-based drug discovery of the synthetic small molecule HSP90 inhibitor AT13387
    Murray, Christopher W.
    Carr, Maria G.
    Chessari, Gianni
    Congreve, Miles
    Coyle, Joseph E.
    Day, Philip J.
    Fazal, Lynsey
    Frederickson, Martyn
    Graham, Brent
    Lewis, Jonathan
    McMenamin, Rachel
    O'Brien, Alistair
    Patel, Sahil
    Williams, Glyn
    Woodhead, Andrew J.
    Woolford, Alison J.
    [J]. MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [6] Heat-Shock Protein 90 (Hsp90) as Anticancer Target for Drug Discovery: An Ample Computational Perspective
    Kumalo, Hezekiel M.
    Bhakat, Soumendranath
    Soliman, Mahmoud E.
    [J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 86 (05) : 1131 - 1160
  • [7] Development of Computational Approaches with a Fragment-Based Drug Design Strategy: In Silico Hsp90 Inhibitors Discovery
    Leon, Roberto
    Soto-Delgado, Jorge
    Montero, Elizabeth
    Vargas, Matias
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (24)
  • [8] Interaction of cepharanthine with immobilized heat shock protein 90α (Hsp90α) and screening of Hsp90α inhibitors
    Haginaka, Jun
    Kitabatake, Tomoko
    Hirose, Iyo
    Matsunaga, Hisami
    Moaddel, Ruin
    [J]. ANALYTICAL BIOCHEMISTRY, 2013, 434 (01) : 202 - 206
  • [9] Multiple fragment-based design strategies leading to the discovery of novel Hsp90 inhibitors
    Kunzer, Aaron R.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [10] Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency
    Murray, Christopher W.
    Carr, Maria G.
    Callaghan, Owen
    Chessari, Gianni
    Congreve, Miles
    Cowan, Suzanna
    Coyle, Joseph E.
    Downham, Robert
    Figueroa, Eva
    Frederickson, Martyn
    Graham, Brent
    McMenamin, Rachel
    O'Brien, M. Alistair
    Patel, Sahli
    Phillips, Theresa R.
    Williams, Glyn
    Woodhead, Andrew J.
    Woolford, Alison J. -A.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (16) : 5942 - 5955