Challenges for epigenetic research in inflammatory bowel diseases

被引：16

作者：

Kellermayer, Richard ^{[1
]}

机构：

[1] USDA ARS, Sect Pediat Gastroenterol, Dept Pediat, Baylor Coll Med,Texas Childrens Hosp,Childrens Nu, Houston, TX 77030 USA

来源：

EPIGENOMICS | 2017年 / 9卷 / 04期

关键词：

PEDIATRIC ULCERATIVE-COLITIS; POUCH-ANAL ANASTOMOSIS; ONSET CROHNS-DISEASE; POPULATION-BASED COHORT; DNA METHYLATION; METASTABLE EPIALLELE; MONOZYGOTIC TWINS; GUT MICROBIOME; UNITED-STATES; INTESTINAL EPITHELIUM;

D O I：

10.2217/epi-2016-0155

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The human epigenome may link environmental exposures and commensal microbiota changes to host pathology in respect to the developmental origins of inflammatory bowel diseases (ulcerative colitis [UC] and Crohn's disease [more appropriately Crohn disease, CD]). Genetic predisposition - prenatal, perinatal and pediatric environmental influences - microbiome aberration (dysbiosis) and immune dysregulation appear to be important elements in disease development, progression and maintenance. The prevalence of combined genetic and epigenetic susceptibility toward UC and CD is calculated herein to be as high as 2%, and approximately 1% for UC and CD in highly developed countries, respectively. This review emphasizes the significant challenges for epigenetic research in inflammatory bowel diseases. Overcoming these challenges, however, could reveal unique opportunities for disease prevention, treatment and possible cure.

引用

页码：527 / 538

页数：12

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