Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-γ production by tumor-associated macrophages

被引：34

作者：

Komohara, Yoshihiro ^{[1
]}

Takemura, Kenichi ^{[1
]}

Lei, Xiao Feng ^{[1
]}

Sakashita, Naomi ^{[1
]}

Harada, Mamoru ^{[2
]}

Suzuki, Hiroshi ^{[3
]}

Kodama, Tatsuhiko ^{[4
]}

Takeya, Motohiro ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Cell Pathol, Kumamoto 860, Japan

[2] Shimane Univ, Sch Med, Dept Immunol, Izumo, Shimane, Japan

[3] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido, Japan

[4] Univ Tokyo, Adv Sci & Technol Res Ctr, Dept Mol Biol & Med, Tokyo, Japan

来源：

CANCER SCIENCE | 2009年 / 100卷 / 11期

关键词：

SCAVENGER RECEPTOR-TYPE; APOPTOTIC CELLS; CANCER; PROGRESSION; ACTIVATION; POLARIZATION; MECHANISMS; EXPRESSION; PHENOTYPE; LIPOPOLYSACCHARIDE;

D O I：

10.1111/j.1349-7006.2009.01296.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Class A scavenger receptors (SR-A, CD204) are highly expressed in tumor-associated macrophages (TAM). To investigate the function of SR-A in TAM, wild-type and SR-A-deficient (SR-A-/-) mice were injected with EL4 cells. Although these groups of mice did not differ in the numbers of infiltrating macrophages and lymphocytes and in neovascularization, SR-A-/- mice had delayed growth of EL4 tumors. Expression of inducible nitric oxide (NO) synthase and interferon (IFN)-gamma mRNA increased significantly in tumor tissues from SR-A-/- mice. Engulfment of necrotic EL4 cells induced upregulation of NO and IFN-gamma production by cultured macrophages, and production of NO and IFN-gamma increased in SR-A-/- macrophages in vitro. IFN-beta production by cultured macrophages was also elevated in SR-A-/- macrophages in vitro. These results suggested that the antitumor activity of macrophages increased in SR-A-/- mice because of upregulation of NO and IFN-gamma production. These data indicate an important role of SR-A in regulating TAM function by inhibiting toll-like receptor (TLR)4-IFN-beta signaling. (Cancer Sci 2009); 00: 000-000).

引用

页码：2160 / 2166

页数：7

共 6 条

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Arnold, RE
Weigent, DA
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Arnold, RE
Weigent, DA
FASEB JOURNAL, 2002, 16 (05): : A1083 - A1083
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Myriam Baratin
Marianne Ziol
Raphäelle Romieu
Michèle Kayibanda
Fabrice Gouilleux
Pascale Briand
Pierre Leroy
Hedi Haddada
Laurent Rénia
Mireille Viguier
Jean-Gérard Guillet
Cancer Gene Therapy, 2001, 8 : 193 - 202
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Baratin, M
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Briand, P
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Haddada, H
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CANCER GENE THERAPY, 2001, 8 (03) : 193 - 202
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Abe, K
Harada, M
Tamada, K
Ito, O
Li, TL
Nomoto, K
CANCER IMMUNOLOGY IMMUNOTHERAPY, 1998, 45 (05) : 225 - 233
[6] Early-appearing tumor-infiltrating natural killer cells play an important role in the nitric oxide production of tumor-associated macrophages through their interferon production
Abe K.
Harada M.
Tamada K.
Ito O.
Li T.
Nomoto K.
Cancer Immunology, Immunotherapy, 1997, 45 (5) : 225 - 233

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