Synthesis, characterization, DNA binding and cleavage studies of chiral Ru(II) salen complexes

被引：32
|
作者：
Khan, Noor-ul H. [1 ]
Pandya, Nirali [1 ]
Kureshy, Rukhsana I. [1 ]
Abdi, Sayed H. R. [1 ]
Agrawal, Santosh [1 ]
Bajaj, Hari C. [1 ]
Pandya, Jagruti [2 ]
Gupte, Akashya [2 ]
机构：
[1] Cent Salt & Marine Chem Res Inst, Discipline Inorgan Mat & Catalysis, CSIR, Bhavnagar 364002, Gujarat, India
[2] Natubhai V Patel Coll Pure & Appl Sci, Vallabh Vidhyanagar, India
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2009年 / 74卷 / 01期
关键词：
Chiral Ru(II) salen; DNA cleavage; Anti microbial; CT-DNA binding; Metallointercalator; LIGAND RUTHENIUM(II) COMPLEXES; COPPER(II) COMPLEXES; BIOLOGICAL-ACTIVITY; CU(II) COMPLEXES; BASE COMPLEXES; CYTOTOXICITY; PHOTOCLEAVAGE; PLATINUM(II); DISCRIMINATION; ALDEHYDES;
D O I：
10.1016/j.saa.2009.05.016
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Interaction of chiral Ru(II) salen complexes (S)-1 and (R)-1 with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, CD measurements, thermal denaturation study and cleavage studies by agarose gel electrophoresis. The DNA binding affinity of (S)-1 (6.25 x 10(3) M-1) was found to be greater than (R)-1 (3.0 x 10(3) M-1). The antimicrobial studies of these complexes on five different gram (+)/(-) bacteria and three different fungal organisms showed selective inhibition of the growth of gram (+) bacteria and were not affective against gram (-) and fungal organisms. Further, the (S)-1 enantiomer inhibited the growth of organisms to a greater extent as compared to (R)-1 enantiomer. (C) 2009 Elsevier B.V. All rights reserved.
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收藏
页码：113 / 119
页数：7
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