Pattern of semantic memory impairment in dementia of Alzheimer's type

The specific pattern of semantic memory impairment in patients with dementia of Alzheimer's type (DAT) remains unclear. Specifically, the presence of a category-specific deficit for biological concepts (reflected in anomia for these concepts) has been questioned. We studied 9 DAT patients using a semantic association judgement test in which they had to decide which of the two given words was most like a target word (e.g., lamb goat, sheep). The 150 target words were drawn from 6 categories: animals, clothing and furniture, fruits and vegetables, tools, action verbs, and abstract nouns. Age- and education-matched control subjects performance equivalently (between 86 and 90% correct) in all categories. Compared to control subjects, DAT patients made significantly more errors in abstract and biological nouns, but not in verbs and man-made artifacts. This pattern of semantic memory impair ment-a sparing of verbs and a selective deficit of nouns in the biological category-has been documented in patients with temporal lobe damage, suggesting a critical dysfunction in the temporal lobes of DAT. (C) 2000 Academic Press.